Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study
Abstract Purpose To examine racial and ethnic disparities in Health-Related Quality of Life (HRQOL) in older adults with breast cancer, both pre- and post-diagnosis. Methods Using the SEER-MHOS database, we included patients ≥ 65 years old with breast cancer who completed the Health Outcomes Survey...
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BMC
2025-03-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-025-02359-x |
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| author | Nicki Karimi-Mostowfi Fang-I Chu Trudy C. Wu Matthew J. Farrell Wisdom Akingbemi Ann C. Raldow |
| author_facet | Nicki Karimi-Mostowfi Fang-I Chu Trudy C. Wu Matthew J. Farrell Wisdom Akingbemi Ann C. Raldow |
| author_sort | Nicki Karimi-Mostowfi |
| collection | DOAJ |
| description | Abstract Purpose To examine racial and ethnic disparities in Health-Related Quality of Life (HRQOL) in older adults with breast cancer, both pre- and post-diagnosis. Methods Using the SEER-MHOS database, we included patients ≥ 65 years old with breast cancer who completed the Health Outcomes Survey within 24 months pre- and post-diagnosis, and who were non-Hispanic White, non-Hispanic Asian or Pacific Islander, non-Hispanic Black or African American, or Hispanic. HRQOL data was measured via the Physical and Mental Component Summary (PCS, MCS). Univariable and multivariable linear regression models were fitted to assess for potential disparities between races and ethnicities. Results On univariable regression models, a numerical drop in mean scores of PCS and MCS was found among all racial/ethnic groups between pre- and post-diagnosis. Among patients in the pre-diagnosis cohort who would be diagnosed with stage IV breast cancer, race was found to be a predictor of PCS with overall significance (p = 0.04). On the local test, compared with Black individuals, White individuals had higher pre-diagnosis PCS scores (+ 13.32, p = 0.03). Race/ethnicity was not found to be a predictor in PCS or MCS scores otherwise. Conclusion Among older patients diagnosed with stage IV breast cancer, White individuals had better physical HRQOL than Black patients’ pre-diagnosis. The decrease in the numerical HRQOL scores of the physical domain in all groups post-diagnosis highlights the potential negative physical impact of breast cancer has on patients, demonstrating the need for determining the proper resources and support to improve physical HRQOL following diagnosis. |
| format | Article |
| id | doaj-art-7fc7cba97d504209900e4ebfc0cdb0ab |
| institution | DOAJ |
| issn | 1477-7525 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj-art-7fc7cba97d504209900e4ebfc0cdb0ab2025-08-20T02:49:16ZengBMCHealth and Quality of Life Outcomes1477-75252025-03-012311910.1186/s12955-025-02359-xTrends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database studyNicki Karimi-Mostowfi0Fang-I Chu1Trudy C. Wu2Matthew J. Farrell3Wisdom Akingbemi4Ann C. Raldow5Lewis Katz School of Medicine, Temple UniversityUCLA Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Westwood Radiation OncologyUCLA Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Westwood Radiation OncologyUCLA Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Westwood Radiation OncologyDrexel University College of MedicineUCLA Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Westwood Radiation OncologyAbstract Purpose To examine racial and ethnic disparities in Health-Related Quality of Life (HRQOL) in older adults with breast cancer, both pre- and post-diagnosis. Methods Using the SEER-MHOS database, we included patients ≥ 65 years old with breast cancer who completed the Health Outcomes Survey within 24 months pre- and post-diagnosis, and who were non-Hispanic White, non-Hispanic Asian or Pacific Islander, non-Hispanic Black or African American, or Hispanic. HRQOL data was measured via the Physical and Mental Component Summary (PCS, MCS). Univariable and multivariable linear regression models were fitted to assess for potential disparities between races and ethnicities. Results On univariable regression models, a numerical drop in mean scores of PCS and MCS was found among all racial/ethnic groups between pre- and post-diagnosis. Among patients in the pre-diagnosis cohort who would be diagnosed with stage IV breast cancer, race was found to be a predictor of PCS with overall significance (p = 0.04). On the local test, compared with Black individuals, White individuals had higher pre-diagnosis PCS scores (+ 13.32, p = 0.03). Race/ethnicity was not found to be a predictor in PCS or MCS scores otherwise. Conclusion Among older patients diagnosed with stage IV breast cancer, White individuals had better physical HRQOL than Black patients’ pre-diagnosis. The decrease in the numerical HRQOL scores of the physical domain in all groups post-diagnosis highlights the potential negative physical impact of breast cancer has on patients, demonstrating the need for determining the proper resources and support to improve physical HRQOL following diagnosis.https://doi.org/10.1186/s12955-025-02359-xBreast cancerHRQOLRacial disparitiesEthnic disparitiesQuality of life |
| spellingShingle | Nicki Karimi-Mostowfi Fang-I Chu Trudy C. Wu Matthew J. Farrell Wisdom Akingbemi Ann C. Raldow Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study Health and Quality of Life Outcomes Breast cancer HRQOL Racial disparities Ethnic disparities Quality of life |
| title | Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study |
| title_full | Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study |
| title_fullStr | Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study |
| title_full_unstemmed | Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study |
| title_short | Trends in racial and ethnic disparities in the health-related quality of life of older adults with breast cancer: a SEER-MHOS national database study |
| title_sort | trends in racial and ethnic disparities in the health related quality of life of older adults with breast cancer a seer mhos national database study |
| topic | Breast cancer HRQOL Racial disparities Ethnic disparities Quality of life |
| url | https://doi.org/10.1186/s12955-025-02359-x |
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