A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin
A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromo...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2019/4763015 |
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| author | Robin A. Reddeman Róbert Glávits John R. Endres Amy E. Clewell Gábor Hirka Adél Vértesi Erzsébet Béres Ilona Pasics Szakonyiné |
| author_facet | Robin A. Reddeman Róbert Glávits John R. Endres Amy E. Clewell Gábor Hirka Adél Vértesi Erzsébet Béres Ilona Pasics Szakonyiné |
| author_sort | Robin A. Reddeman |
| collection | DOAJ |
| description | A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. |
| format | Article |
| id | doaj-art-7fc7290607e64548b9879f37f633527e |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-7fc7290607e64548b9879f37f633527e2025-08-20T02:08:36ZengWileyJournal of Toxicology1687-81911687-82052019-01-01201910.1155/2019/47630154763015A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% MangiferinRobin A. Reddeman0Róbert Glávits1John R. Endres2Amy E. Clewell3Gábor Hirka4Adél Vértesi5Erzsébet Béres6Ilona Pasics Szakonyiné7AIBMR Life Sciences, Inc., 2800 E. Madison St., Suite 202, Seattle, WA 98373, USATOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, HungaryAIBMR Life Sciences, Inc., 2800 E. Madison St., Suite 202, Seattle, WA 98373, USAAIBMR Life Sciences, Inc., 2800 E. Madison St., Suite 202, Seattle, WA 98373, USATOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, HungaryTOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, HungaryTOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, HungaryTOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, HungaryA battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.http://dx.doi.org/10.1155/2019/4763015 |
| spellingShingle | Robin A. Reddeman Róbert Glávits John R. Endres Amy E. Clewell Gábor Hirka Adél Vértesi Erzsébet Béres Ilona Pasics Szakonyiné A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin Journal of Toxicology |
| title | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| title_full | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| title_fullStr | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| title_full_unstemmed | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| title_short | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| title_sort | toxicological evaluation of mango leaf extract mangifera indica containing 60 mangiferin |
| url | http://dx.doi.org/10.1155/2019/4763015 |
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