Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity
Hepatocarcinoma is one of the most prevalent gastroenterological cancers in the world with less effective therapy. As an oncofetal antigen and diagnostic marker for liver cancer, alpha-fetoprotein (AFP) possesses a variety of biological functions. Except for its diagnosis in liver cancer, AFP has be...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/9049252 |
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| _version_ | 1832554369792344064 |
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| author | Xiaoping Wang Qiaoxia Wang |
| author_facet | Xiaoping Wang Qiaoxia Wang |
| author_sort | Xiaoping Wang |
| collection | DOAJ |
| description | Hepatocarcinoma is one of the most prevalent gastroenterological cancers in the world with less effective therapy. As an oncofetal antigen and diagnostic marker for liver cancer, alpha-fetoprotein (AFP) possesses a variety of biological functions. Except for its diagnosis in liver cancer, AFP has become a target for liver cancer immunotherapy. Although the immunogenicity of AFP is weak and it could induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes, AFP has attracted more attention in liver cancer immunotherapy. By in vitro modification, the immunogenicity and immune response of AFP could be enhanced. AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer. |
| format | Article |
| id | doaj-art-7fc4fdaea07d4562a41320d9073660e7 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-7fc4fdaea07d4562a41320d9073660e72025-02-03T05:51:40ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/90492529049252Alpha-Fetoprotein and Hepatocellular Carcinoma ImmunityXiaoping Wang0Qiaoxia Wang1Laboratory of Molecular Biology & Pathology, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, ChinaDepartment of Infectious Diseases, Xi’an Central Hospital, Xi’an, Shaanxi 710000, ChinaHepatocarcinoma is one of the most prevalent gastroenterological cancers in the world with less effective therapy. As an oncofetal antigen and diagnostic marker for liver cancer, alpha-fetoprotein (AFP) possesses a variety of biological functions. Except for its diagnosis in liver cancer, AFP has become a target for liver cancer immunotherapy. Although the immunogenicity of AFP is weak and it could induce the immune escapes through inhibiting the function of dendritic cells, natural killer cells, and T lymphocytes, AFP has attracted more attention in liver cancer immunotherapy. By in vitro modification, the immunogenicity and immune response of AFP could be enhanced. AFP-modified immune cell vaccine or peptide vaccine has displayed the specific antitumor immunity against AFP-positive tumor cells and laid a better foundation for the immunotherapy of liver cancer.http://dx.doi.org/10.1155/2018/9049252 |
| spellingShingle | Xiaoping Wang Qiaoxia Wang Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity Canadian Journal of Gastroenterology and Hepatology |
| title | Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity |
| title_full | Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity |
| title_fullStr | Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity |
| title_full_unstemmed | Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity |
| title_short | Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity |
| title_sort | alpha fetoprotein and hepatocellular carcinoma immunity |
| url | http://dx.doi.org/10.1155/2018/9049252 |
| work_keys_str_mv | AT xiaopingwang alphafetoproteinandhepatocellularcarcinomaimmunity AT qiaoxiawang alphafetoproteinandhepatocellularcarcinomaimmunity |