A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67
<b>Background and Clinical Significance:</b> Abnormal uterine bleeding during the postmenopausal years is a pathological sign that may be due to simultaneous intrauterine and ovarian pathology. Granulosa cell tumours of the ovary are malignant neoplasms producing oestradiol, which leads...
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2024-11-01
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| author | Krum Vladov Ekaterina Uchikova Maria Koleva-Ivanova Kamen Yamakov Veselin Belovezhdov Gita Yamakova-Vladova Eleonora Hristova-Atanasova |
| author_facet | Krum Vladov Ekaterina Uchikova Maria Koleva-Ivanova Kamen Yamakov Veselin Belovezhdov Gita Yamakova-Vladova Eleonora Hristova-Atanasova |
| author_sort | Krum Vladov |
| collection | DOAJ |
| description | <b>Background and Clinical Significance:</b> Abnormal uterine bleeding during the postmenopausal years is a pathological sign that may be due to simultaneous intrauterine and ovarian pathology. Granulosa cell tumours of the ovary are malignant neoplasms producing oestradiol, which leads to the abnormal proliferation of the endometrium, precancerous lesions, and endometrial carcinoma type I. <b>Case Presentation:</b> The authors present a clinical case of a 67-year-old woman with postmenopausal bleeding who underwent a total abdominal hysterectomy with bilateral adnexectomy, pelvic lymphadenectomy, and partial omentectomy. The histopathological examination showed a granulosa cell adult-type ovarian tumour and a malignant endometrial polyp with atypical hyperplasia of the endometrium. <b>Conclusions:</b> The immunohistochemical analysis of the malignant endometrial polyp confirmed the expression of oestrogen, progesterone receptors, and the biomarker Ki-67. |
| format | Article |
| id | doaj-art-7fc4fd3a54904fe49ed4ca7decd63613 |
| institution | DOAJ |
| issn | 2571-841X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj-art-7fc4fd3a54904fe49ed4ca7decd636132025-08-20T02:56:51ZengMDPI AGReports2571-841X2024-11-017410310.3390/reports7040103A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67Krum Vladov0Ekaterina Uchikova1Maria Koleva-Ivanova2Kamen Yamakov3Veselin Belovezhdov4Gita Yamakova-Vladova5Eleonora Hristova-Atanasova6Clinic of Obstetrics and Gynecology, University Hospital “St. George”, 4000 Plovdiv, BulgariaClinic of Obstetrics and Gynecology, University Hospital “St. George”, 4000 Plovdiv, BulgariaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaClinic of Obstetrics and Gynecology, University Hospital “St. George”, 4000 Plovdiv, BulgariaDepartment of General and Clinical Pathology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaClinic of Obstetrics and Gynecology, University Hospital “St. George”, 4000 Plovdiv, BulgariaDepartment of Social Medicine and Public Health, Faculty of Public Health, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria<b>Background and Clinical Significance:</b> Abnormal uterine bleeding during the postmenopausal years is a pathological sign that may be due to simultaneous intrauterine and ovarian pathology. Granulosa cell tumours of the ovary are malignant neoplasms producing oestradiol, which leads to the abnormal proliferation of the endometrium, precancerous lesions, and endometrial carcinoma type I. <b>Case Presentation:</b> The authors present a clinical case of a 67-year-old woman with postmenopausal bleeding who underwent a total abdominal hysterectomy with bilateral adnexectomy, pelvic lymphadenectomy, and partial omentectomy. The histopathological examination showed a granulosa cell adult-type ovarian tumour and a malignant endometrial polyp with atypical hyperplasia of the endometrium. <b>Conclusions:</b> The immunohistochemical analysis of the malignant endometrial polyp confirmed the expression of oestrogen, progesterone receptors, and the biomarker Ki-67.https://www.mdpi.com/2571-841X/7/4/103abnormal uterine bleedingendometrial polypsovarian tumoursoestrogen receptorprogesterone receptor |
| spellingShingle | Krum Vladov Ekaterina Uchikova Maria Koleva-Ivanova Kamen Yamakov Veselin Belovezhdov Gita Yamakova-Vladova Eleonora Hristova-Atanasova A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 Reports abnormal uterine bleeding endometrial polyps ovarian tumours oestrogen receptor progesterone receptor |
| title | A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 |
| title_full | A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 |
| title_fullStr | A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 |
| title_full_unstemmed | A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 |
| title_short | A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67 |
| title_sort | case report of the synchronous occurrence of ovarian granulosa cell tumour and malignant endometrial polyp with immunohistochemical expression of hormone receptors and biomarkers p 53 and ki 67 |
| topic | abnormal uterine bleeding endometrial polyps ovarian tumours oestrogen receptor progesterone receptor |
| url | https://www.mdpi.com/2571-841X/7/4/103 |
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