Correlation between serum vitamin D level and acute invasive enteritis in children
Abstract Background Diarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1‐mediated intestinal inflammation. This study aimed...
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Wiley
2024-09-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70024 |
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| author | Lingrong Yang Yu Fang Jinyu Zheng Qiaoying Zhu Li Tang Fu Xiong |
| author_facet | Lingrong Yang Yu Fang Jinyu Zheng Qiaoying Zhu Li Tang Fu Xiong |
| author_sort | Lingrong Yang |
| collection | DOAJ |
| description | Abstract Background Diarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1‐mediated intestinal inflammation. This study aimed to investigate the effects of serum vitamin D levels on acute invasive enteritis in children. Methods This prospective cohort study included 82 children aged 1–3 years with clinically diagnosed acute invasive enteritis at Sichuan Maternal and Child Health Hospital from February 2021 to February 2022, alongside a control group of 80 healthy children. Fecal specimens were collected for routine tests and occult blood analysis, while blood samples were taken for routine tests, C‐reactive protein, and 25‐OHD levels. Comparative analyses were performed between groups, and multifactorial logistic regression was used to identify factors influencing invasive enteritis. Results The study group showed significantly lower serum 25‐OHD levels (27.95 ± 9.91 ng/mL) compared to controls (32.76 ± 10.23 ng/mL, p < .01). Among the study group, 19.5% (16/82) had levels <20 ng/mL, versus 12.5% (10/80) in controls. Regular vitamin D supplementation was lower in the study group (58.5% vs. 77.5%, p < .05). Outdoor activity duration was also reduced (2.57 ± 0.98 h vs. 3.04 ± 0.88 h, p < .01). Multivariate analysis identified that exclusive breastfeeding, greater outdoor activity time and regular vitamin D supplementation were all associated with reduced risk of invasive enteritis (p < .05). Conclusion The findings indicate an association between low serum 25‐OHD levels and acute invasive enteritis in children aged 1‐3 years, suggesting that consistent vitamin D supplementation and sufficient outdoor activity may protect against this condition. |
| format | Article |
| id | doaj-art-7fc08f5f7a384047b19fb4ecb439ef54 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-7fc08f5f7a384047b19fb4ecb439ef542025-08-20T02:09:35ZengWileyImmunity, Inflammation and Disease2050-45272024-09-01129n/an/a10.1002/iid3.70024Correlation between serum vitamin D level and acute invasive enteritis in childrenLingrong Yang0Yu Fang1Jinyu Zheng2Qiaoying Zhu3Li Tang4Fu Xiong5Sichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan ChinaThe Second School of Medicine Wenzhou Medical University Wenzhou Zhejiang ChinaThe Second School of Medicine Wenzhou Medical University Wenzhou Zhejiang ChinaSichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan ChinaSichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan ChinaSichuan Provincial Maternity and Child Health Care Hospital Women and Children's Hospital of Chengdu Medical College Chengdu Sichuan ChinaAbstract Background Diarrhea is a leading cause of death in young children worldwide. Vitamin D deficiency impairs the body's ability to clear pathogens, reduces tight junction protein expression in intestinal epithelial cells, and enhances Th1‐mediated intestinal inflammation. This study aimed to investigate the effects of serum vitamin D levels on acute invasive enteritis in children. Methods This prospective cohort study included 82 children aged 1–3 years with clinically diagnosed acute invasive enteritis at Sichuan Maternal and Child Health Hospital from February 2021 to February 2022, alongside a control group of 80 healthy children. Fecal specimens were collected for routine tests and occult blood analysis, while blood samples were taken for routine tests, C‐reactive protein, and 25‐OHD levels. Comparative analyses were performed between groups, and multifactorial logistic regression was used to identify factors influencing invasive enteritis. Results The study group showed significantly lower serum 25‐OHD levels (27.95 ± 9.91 ng/mL) compared to controls (32.76 ± 10.23 ng/mL, p < .01). Among the study group, 19.5% (16/82) had levels <20 ng/mL, versus 12.5% (10/80) in controls. Regular vitamin D supplementation was lower in the study group (58.5% vs. 77.5%, p < .05). Outdoor activity duration was also reduced (2.57 ± 0.98 h vs. 3.04 ± 0.88 h, p < .01). Multivariate analysis identified that exclusive breastfeeding, greater outdoor activity time and regular vitamin D supplementation were all associated with reduced risk of invasive enteritis (p < .05). Conclusion The findings indicate an association between low serum 25‐OHD levels and acute invasive enteritis in children aged 1‐3 years, suggesting that consistent vitamin D supplementation and sufficient outdoor activity may protect against this condition.https://doi.org/10.1002/iid3.7002425‐hydroxyvitamin Dacute invasive enteritischildreninfectious diarrheavitamin D |
| spellingShingle | Lingrong Yang Yu Fang Jinyu Zheng Qiaoying Zhu Li Tang Fu Xiong Correlation between serum vitamin D level and acute invasive enteritis in children Immunity, Inflammation and Disease 25‐hydroxyvitamin D acute invasive enteritis children infectious diarrhea vitamin D |
| title | Correlation between serum vitamin D level and acute invasive enteritis in children |
| title_full | Correlation between serum vitamin D level and acute invasive enteritis in children |
| title_fullStr | Correlation between serum vitamin D level and acute invasive enteritis in children |
| title_full_unstemmed | Correlation between serum vitamin D level and acute invasive enteritis in children |
| title_short | Correlation between serum vitamin D level and acute invasive enteritis in children |
| title_sort | correlation between serum vitamin d level and acute invasive enteritis in children |
| topic | 25‐hydroxyvitamin D acute invasive enteritis children infectious diarrhea vitamin D |
| url | https://doi.org/10.1002/iid3.70024 |
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