System metabolic engineering modification of Saccharomyces cerevisiae to increase SAM production

System metabolic engineering modification of Saccharomyces cerevisiae to increase SAM production

Abstract S-adenosyl-L-methionine (SAM) is an important compound with significant pharmaceutical and nutraceutical applications. Currently, microbial fermentation is dominant in SAM production, which remains challenging due to its complex biosynthetic pathway and insufficient precursor availability....

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Bibliographic Details
Main Authors: Liangzhuang Tan, Yuehan Zhang, Ping Liu, Yihang Wu, Zuoyu Huang, Zhongce Hu, Zhiqiang Liu, Yuanshan Wang, Yuguo Zheng
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:Bioresources and Bioprocessing
Subjects:
S-adenosyl-L-Methionine
Saccharomyces cerevisiae
CRISPR/Cas9 system
Combinatorial metabolic engineering
Fed-batch fermentation
TCA cycle
Online Access:https://doi.org/10.1186/s40643-025-00858-9
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