Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.

Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.

The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70S6K1 dependent phosphorylation of Pdcd4 followed by β-TrCP1-mediated ubiquitination, and proteas...

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Main Authors: Tobias Schmid, Johanna S Blees, Magdalena M Bajer, Janine Wild, Luca Pescatori, Giuliana Cuzzucoli Crucitti, Luigi Scipione, Roberta Costi, Curtis J Henrich, Bernhard Brüne, Nancy H Colburn, Roberto Di Santo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0151643
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