A novel mouse model for studying complications related to type 2 diabetes using a medium-fat diet, fructose, and streptozotocin

Abstract The study of type 2 diabetes mellitus (T2DM) pathophysiology relies mainly on the use of animal models, the most common of which involves the consumption of high-fat diets comprising 60% calories from fat. Although these models reproduce the onset and most complications associated with T2DM...

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Main Authors: Yanina Luciana Mazzocco, Gastón Bergero, Sebastian Del Rosso, Zoé Magalí Cejas Gallardo, Alejandra Mariel Canalis, Ruth Eliana Baigorri, Luciana Mezzano, Juan Javier Mladin, Gustavo Tomás Díaz-Gerevini, Claudia Martínez Benavidez, Roxana Carolina Cano, Maria Pilar Aoki
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-04335-3
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