Role of Sialic Acids in Central Nervous System Immune Response
Sialic acids (Sia) are a structurally diverse family of nine-carbon sugars that play a crucial role in cell–cell communication, immune modulation, and neurodevelopment. Their unique ability to form homo- and oligo-polymers, along with a variety of linkages and chemical modifications, contributes to...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-06-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/61204 |
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| author | Karolina Narejko Martyna Niemczuk Agata Urbaniak Sylwia Koziej Piotr Jakub Depta Adrianna Jasiuk Mateusz Wiekiera |
| author_facet | Karolina Narejko Martyna Niemczuk Agata Urbaniak Sylwia Koziej Piotr Jakub Depta Adrianna Jasiuk Mateusz Wiekiera |
| author_sort | Karolina Narejko |
| collection | DOAJ |
| description |
Sialic acids (Sia) are a structurally diverse family of nine-carbon sugars that play a crucial role in cell–cell communication, immune modulation, and neurodevelopment. Their unique ability to form homo- and oligo-polymers, along with a variety of linkages and chemical modifications, contributes to the complexity of glycosylation patterns on cell surfaces. Particularly enriched in the Central Nervous System (CNS), polysialic acids are involved in processes such as synaptogenesis, neuroplasticity, and modulation of neurotransmitter activity. This study explores the biosynthesis, recycling, and functional roles of Sia in the CNS, emphasizing their involvement in immune regulation via SIGLEC receptors and complement system modulation. It also addresses the pathological implications of Sia mimicry by pathogens such as Neisseria meningitidis and E. coli, which exploit sialylation to evade immune responses.
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| format | Article |
| id | doaj-art-7fb77f83f83a47b3a36d82ac850afcc7 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-7fb77f83f83a47b3a36d82ac850afcc72025-08-20T03:27:36ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-06-014210.12775/QS.2025.42.61204Role of Sialic Acids in Central Nervous System Immune ResponseKarolina Narejko0https://orcid.org/0009-0000-0564-4401Martyna Niemczuk1https://orcid.org/0009-0006-5877-6356Agata Urbaniak2https://orcid.org/0009-0003-2404-4833Sylwia Koziej3https://orcid.org/0009-0002-9607-6693Piotr Jakub Depta4https://orcid.org/0009-0008-1081-3212Adrianna Jasiuk5https://orcid.org/0009-0001-4829-3768Mateusz Wiekiera6https://orcid.org/0009-0003-9236-2913MSWiA Hospital, BiałystokMedical University of BiałystokMedical University of BialystokStefan Cardinal Wyszyński Provincial Specialist Hospital SPZOZ ,LublinMSWiA Hospital, BiałystokMedical Univeristy of ŁódźMedical Univeristy of Łódź Sialic acids (Sia) are a structurally diverse family of nine-carbon sugars that play a crucial role in cell–cell communication, immune modulation, and neurodevelopment. Their unique ability to form homo- and oligo-polymers, along with a variety of linkages and chemical modifications, contributes to the complexity of glycosylation patterns on cell surfaces. Particularly enriched in the Central Nervous System (CNS), polysialic acids are involved in processes such as synaptogenesis, neuroplasticity, and modulation of neurotransmitter activity. This study explores the biosynthesis, recycling, and functional roles of Sia in the CNS, emphasizing their involvement in immune regulation via SIGLEC receptors and complement system modulation. It also addresses the pathological implications of Sia mimicry by pathogens such as Neisseria meningitidis and E. coli, which exploit sialylation to evade immune responses. https://apcz.umk.pl/QS/article/view/61204Sialic Acidsimmune systemCNSsialylationsialyltransferasesSIGLEC |
| spellingShingle | Karolina Narejko Martyna Niemczuk Agata Urbaniak Sylwia Koziej Piotr Jakub Depta Adrianna Jasiuk Mateusz Wiekiera Role of Sialic Acids in Central Nervous System Immune Response Quality in Sport Sialic Acids immune system CNS sialylation sialyltransferases SIGLEC |
| title | Role of Sialic Acids in Central Nervous System Immune Response |
| title_full | Role of Sialic Acids in Central Nervous System Immune Response |
| title_fullStr | Role of Sialic Acids in Central Nervous System Immune Response |
| title_full_unstemmed | Role of Sialic Acids in Central Nervous System Immune Response |
| title_short | Role of Sialic Acids in Central Nervous System Immune Response |
| title_sort | role of sialic acids in central nervous system immune response |
| topic | Sialic Acids immune system CNS sialylation sialyltransferases SIGLEC |
| url | https://apcz.umk.pl/QS/article/view/61204 |
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