Branched PLGA derivatives with tailored drug delivery properties
Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with othe...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0011 |
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| author | Snejdrova Eva Podzimek Stepan Martiska Juraj Holas Ondrej Dittrich Milan |
| author_facet | Snejdrova Eva Podzimek Stepan Martiska Juraj Holas Ondrej Dittrich Milan |
| author_sort | Snejdrova Eva |
| collection | DOAJ |
| description | Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic-co-glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. A series of poly(lactic-co-glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid. The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties. |
| format | Article |
| id | doaj-art-7fb444a204684cf5923ba279868bf98a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-7fb444a204684cf5923ba279868bf98a2025-02-03T06:59:07ZengSciendoActa Pharmaceutica1846-95582020-03-01701637510.2478/acph-2020-0011acph-2020-0011Branched PLGA derivatives with tailored drug delivery propertiesSnejdrova Eva0Podzimek Stepan1Martiska Juraj2Holas Ondrej3Dittrich Milan4Charles University, Faculty of Pharmacy, 500 05Hradec Kralove Czech RepublicSYNPO, 532 07Pardubice, Czech RepublicCharles University, Faculty of Pharmacy, 500 05Hradec Kralove Czech RepublicCharles University, Faculty of Pharmacy, 500 05Hradec Kralove Czech RepublicCharles University, Faculty of Pharmacy, 500 05Hradec Kralove Czech RepublicDespite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic-co-glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. A series of poly(lactic-co-glycolic acid) derivatives with lower molar mass and star or comb architecture were synthesized by a simple, catalyst free, direct melt polycondensation method not requiring purification of the obtained sterile product by precipitation. Branching monomers used were mannitol, pentaerythritol, dipentaerythritol, tripentaerythritol and polyacrylic acid. The products were characterized by molar mass averages, average branching ratio, rheological and thermal properties.https://doi.org/10.2478/acph-2020-0011plgabranchingstar polymerpolymer synthesislight scattering |
| spellingShingle | Snejdrova Eva Podzimek Stepan Martiska Juraj Holas Ondrej Dittrich Milan Branched PLGA derivatives with tailored drug delivery properties Acta Pharmaceutica plga branching star polymer polymer synthesis light scattering |
| title | Branched PLGA derivatives with tailored drug delivery properties |
| title_full | Branched PLGA derivatives with tailored drug delivery properties |
| title_fullStr | Branched PLGA derivatives with tailored drug delivery properties |
| title_full_unstemmed | Branched PLGA derivatives with tailored drug delivery properties |
| title_short | Branched PLGA derivatives with tailored drug delivery properties |
| title_sort | branched plga derivatives with tailored drug delivery properties |
| topic | plga branching star polymer polymer synthesis light scattering |
| url | https://doi.org/10.2478/acph-2020-0011 |
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