Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation
Rheumatoid arthritis (RA) is associated with a high rate of hepatitis B virus (HBV) infection. A large proportion of HBV reactivation may occur in RA patients after immunosuppression treatment, while fulminant hepatitis may occur in severe cases. Immunosuppressants are fundamental medications for th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024174750 |
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| author | Fenglin Zhu Miao Wang Xuhong Zhang Guoqing Zhao Hongyan Gao Lamei Zhou |
| author_facet | Fenglin Zhu Miao Wang Xuhong Zhang Guoqing Zhao Hongyan Gao Lamei Zhou |
| author_sort | Fenglin Zhu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is associated with a high rate of hepatitis B virus (HBV) infection. A large proportion of HBV reactivation may occur in RA patients after immunosuppression treatment, while fulminant hepatitis may occur in severe cases. Immunosuppressants are fundamental medications for the treatment of RA but carry the risk of inducing HBV reactivation. This inherent contradiction poses challenges throughout the immunosuppressive treatment process in patients with RA. Recently, numerous studies have been conducted on the contradictory therapeutic mechanisms between RA treatment and HBV infection, including aspects of innate immunity, adaptive immunity, and related signalling pathways. In this article, we review the immunological mechanisms underlying the onset of RA and HBV infections, providing a reference for determining appropriate treatment plans to reduce therapeutic contradictions and thereby reduce the risk of HBV reactivation in patients with RA combined with HBV infection. |
| format | Article |
| id | doaj-art-7fb3f3a07adf4767814555bf1bf376c6 |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-7fb3f3a07adf4767814555bf1bf376c62025-08-20T02:46:43ZengElsevierHeliyon2405-84402025-01-01111e4144410.1016/j.heliyon.2024.e41444Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activationFenglin Zhu0Miao Wang1Xuhong Zhang2Guoqing Zhao3Hongyan Gao4Lamei Zhou5Department of Rheumatology, The First Affiliated Hostipal of Chonqqing University of Chinese Medicine, Chongqing, Jiangbei, 410000, ChinaDepartment of Rheumatology, The First Affiliated Hostipal of Chonqqing University of Chinese Medicine, Chongqing, Jiangbei, 410000, ChinaDepartment of Rheumatology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, 214000, Jiangsu, ChinaDepartment of Rheumatology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, 214000, Jiangsu, ChinaChongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, The First Affiliated Hostipal of Chonqqing University of Chinese Medicine, Chongqing, Jiangbei, 410000, China; Corresponding author.Department of Rheumatology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, 214000, Jiangsu, China; Corresponding author.Rheumatoid arthritis (RA) is associated with a high rate of hepatitis B virus (HBV) infection. A large proportion of HBV reactivation may occur in RA patients after immunosuppression treatment, while fulminant hepatitis may occur in severe cases. Immunosuppressants are fundamental medications for the treatment of RA but carry the risk of inducing HBV reactivation. This inherent contradiction poses challenges throughout the immunosuppressive treatment process in patients with RA. Recently, numerous studies have been conducted on the contradictory therapeutic mechanisms between RA treatment and HBV infection, including aspects of innate immunity, adaptive immunity, and related signalling pathways. In this article, we review the immunological mechanisms underlying the onset of RA and HBV infections, providing a reference for determining appropriate treatment plans to reduce therapeutic contradictions and thereby reduce the risk of HBV reactivation in patients with RA combined with HBV infection.http://www.sciencedirect.com/science/article/pii/S2405844024174750Hepatitis B virus infectionRheumatoid arthritisImmunological mechanism contradictionImmune cellCellular signal transduction pathway |
| spellingShingle | Fenglin Zhu Miao Wang Xuhong Zhang Guoqing Zhao Hongyan Gao Lamei Zhou Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation Heliyon Hepatitis B virus infection Rheumatoid arthritis Immunological mechanism contradiction Immune cell Cellular signal transduction pathway |
| title | Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation |
| title_full | Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation |
| title_fullStr | Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation |
| title_full_unstemmed | Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation |
| title_short | Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation |
| title_sort | contradictory mechanisms of rheumatoid arthritis and hepatitis b virus infection activation |
| topic | Hepatitis B virus infection Rheumatoid arthritis Immunological mechanism contradiction Immune cell Cellular signal transduction pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024174750 |
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