Detecting plasmid-mediated dissemination of blaKPC-3 and blaOXA-48-like genes in Enterobacterales across Finnish healthcare organizations using hybrid genome assembly

Detecting plasmid-mediated dissemination of blaKPC-3 and blaOXA-48-like genes in Enterobacterales across Finnish healthcare organizations using hybrid genome assembly

The spread of carbapenemase-producing Enterobacterales (CPE) is a global concern. While the majority of the CPE outbreaks are due to clonal spread, recent findings highlight the transmission of carbapenemase gene-carrying plasmids across various bacterial species, exacerbated by extensive antibiotic...

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Bibliographic Details
Main Authors: Meeri Piispa, Anni Vainio, Jani Halkilahti, Outi Lyytikäinen, Kati Räisänen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
hybrid assembly
horizontal plasmid-mediated gene transfer
outbreak
molecular epidemiology
plasmid
CPE
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1567913/full
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