Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats
This study aims to assess the daily ingestion of Klanceng Honey (KH) on fasting blood glucose (FBG), high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and pancreatic histopathology. Thirty rats were involved and divided into six groups: G1 = un...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Komunitas Ilmuwan dan Profesional Muslim Indonesia
2024-12-01
|
| Series: | Communications in Science and Technology |
| Subjects: | |
| Online Access: | https://cst.kipmi.or.id/journal/article/view/1503 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560562723454976 |
|---|---|
| author | Agussalim Nafiatul Umami Nurliyani Wan Iryani Wan Ismail Dewi Masyithoh Ustadi Ali Agus |
| author_facet | Agussalim Nafiatul Umami Nurliyani Wan Iryani Wan Ismail Dewi Masyithoh Ustadi Ali Agus |
| author_sort | Agussalim |
| collection | DOAJ |
| description | This study aims to assess the daily ingestion of Klanceng Honey (KH) on fasting blood glucose (FBG), high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and pancreatic histopathology. Thirty rats were involved and divided into six groups: G1 = untreated normal rats, G2 = untreated diabetic rats (DR), G3 = DR treated with 0.9 mg/kg BW glibenclamide, G4, G5, and G6 = DR treated with 1, 2, and 3 g/kg BW KH, respectively for 28 days. The FBG level of G1 was found lower than that of diabetic rat groups (G2–G6) (p<0.01). The TC level of G1 group on 14th and 28th days was lower than that of G2–G6 groups (p<0.01). The TG levels in all rat groups showed no significant difference at 0–28 days. On 14th day, the LDL level of diabetic groups were higher than the one in G1 group (p<0.01). Meanwhile, on 14th and 28th, the HDL levels of G3–G6 groups, were higher than the one in G1 group (p<0.01). The pancreatic histopathology of all rat groups showed no abnormalities of the Langerhans islets. The daily ingestion of KH prevented FBG, TC, TG, and LDL levels from rising, increased the HDL levels, and protected the pancreatic glands against damage. T. laeviceps honey can potentially be used as a functional food for therapy of DM patients. |
| format | Article |
| id | doaj-art-7fab53792c1b4ea8a387937274ebd354 |
| institution | Kabale University |
| issn | 2502-9258 2502-9266 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Komunitas Ilmuwan dan Profesional Muslim Indonesia |
| record_format | Article |
| series | Communications in Science and Technology |
| spelling | doaj-art-7fab53792c1b4ea8a387937274ebd3542025-01-04T01:17:06ZengKomunitas Ilmuwan dan Profesional Muslim IndonesiaCommunications in Science and Technology2502-92582502-92662024-12-019233134210.21924/cst.9.2.2024.15031503Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic ratsAgussalim0Nafiatul Umami1Nurliyani2Wan Iryani Wan Ismail3Dewi Masyithoh4Ustadi5Ali Agus6Department of Animal Nutrition and Feed Science, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Animal Nutrition and Feed Science, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Animal Products Technology, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaCell Signaling and Biotechnology Research Group, Universiti Malaysia Terengganu, Terengganu 21030, MalaysiaFaculty of Animal Husbandry, Universitas Islam Malang, Malang 65144, IndonesiaPT. Kembang Joyo Sriwijaya, Malang 65152, IndonesiaDepartment of Animal Nutrition and Feed Science, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaThis study aims to assess the daily ingestion of Klanceng Honey (KH) on fasting blood glucose (FBG), high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and pancreatic histopathology. Thirty rats were involved and divided into six groups: G1 = untreated normal rats, G2 = untreated diabetic rats (DR), G3 = DR treated with 0.9 mg/kg BW glibenclamide, G4, G5, and G6 = DR treated with 1, 2, and 3 g/kg BW KH, respectively for 28 days. The FBG level of G1 was found lower than that of diabetic rat groups (G2–G6) (p<0.01). The TC level of G1 group on 14th and 28th days was lower than that of G2–G6 groups (p<0.01). The TG levels in all rat groups showed no significant difference at 0–28 days. On 14th day, the LDL level of diabetic groups were higher than the one in G1 group (p<0.01). Meanwhile, on 14th and 28th, the HDL levels of G3–G6 groups, were higher than the one in G1 group (p<0.01). The pancreatic histopathology of all rat groups showed no abnormalities of the Langerhans islets. The daily ingestion of KH prevented FBG, TC, TG, and LDL levels from rising, increased the HDL levels, and protected the pancreatic glands against damage. T. laeviceps honey can potentially be used as a functional food for therapy of DM patients.https://cst.kipmi.or.id/journal/article/view/1503diabetes mellitusfasting blood glucoseinsulinstingless bee honeypancreas gland |
| spellingShingle | Agussalim Nafiatul Umami Nurliyani Wan Iryani Wan Ismail Dewi Masyithoh Ustadi Ali Agus Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats Communications in Science and Technology diabetes mellitus fasting blood glucose insulin stingless bee honey pancreas gland |
| title | Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats |
| title_full | Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats |
| title_fullStr | Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats |
| title_full_unstemmed | Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats |
| title_short | Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats |
| title_sort | klanceng honey tetragonula laeviceps its effect on fasting blood glucose lipid and hematological profiles and pancreatic histopathology of diabetic rats |
| topic | diabetes mellitus fasting blood glucose insulin stingless bee honey pancreas gland |
| url | https://cst.kipmi.or.id/journal/article/view/1503 |
| work_keys_str_mv | AT agussalim klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT nafiatulumami klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT nurliyani klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT waniryaniwanismail klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT dewimasyithoh klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT ustadi klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats AT aliagus klancenghoneytetragonulalaevicepsitseffectonfastingbloodglucoselipidandhematologicalprofilesandpancreatichistopathologyofdiabeticrats |