Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study
Background. This study aimed to clarify whether Parkinson’s disease (PD) and depression were independent risk factors or with synergic effects in dementia. Methods. Newly diagnosed PD (n = 1213) patients and control subjects (n = 4852) were selected from the Taiwan National Health Insurance Research...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/8493916 |
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| author | Ting-Chun Fang Yu-Hsuan Wu Yi-Huei Chen Ching-Heng Lin Ming-Hong Chang |
| author_facet | Ting-Chun Fang Yu-Hsuan Wu Yi-Huei Chen Ching-Heng Lin Ming-Hong Chang |
| author_sort | Ting-Chun Fang |
| collection | DOAJ |
| description | Background. This study aimed to clarify whether Parkinson’s disease (PD) and depression were independent risk factors or with synergic effects in dementia. Methods. Newly diagnosed PD (n = 1213) patients and control subjects (n = 4852) were selected from the Taiwan National Health Insurance Research Database from January 2001 through December 2008. Follow-up ended in 2011 with an outcome of dementia occurring or not. This cohort was divided into controls with or without depression, PD only, and PD with depression. The incident rate of dementia and hazard ratio (HR) using Cox’s regression analysis were calculated for each group. Results. When compared with controls without depression as HR 1.00, the adjusted HR for dementia was 3.29 (p<0.001) in the PD only group, 2.77 (p<0.001) in the PD with depression group, and 1.55 (p=0.024) in the depression only group. The incident rate of dementia was 29.2 (per 1000 person-years) in the PD only group and 13.2 in the PD with depression group. The effect of PD on dementia in the depression group produced a HR of 0.97 (p=0.905). Conclusions. Parkinson’s disease served as a risk factor for dementia. By comparison, depression was not a risk factor for dementia in PD patients, although it did act as a risk factor for dementia. |
| format | Article |
| id | doaj-art-7fa9f50abd9a4a82a1c1d2542af53d69 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7fa9f50abd9a4a82a1c1d2542af53d692025-02-03T01:27:55ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/84939168493916Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort StudyTing-Chun Fang0Yu-Hsuan Wu1Yi-Huei Chen2Ching-Heng Lin3Ming-Hong Chang4Department of Neurology, Taichung Veteran General Hospital, Taichung 40705, Taiwan, ChinaDepartment of Neurology, Taichung Veteran General Hospital, Taichung 40705, Taiwan, ChinaDepartment of Medical Education and Research, Taichung Veteran General Hospital, Taichung 40705, Taiwan, ChinaDepartment of Medical Education and Research, Taichung Veteran General Hospital, Taichung 40705, Taiwan, ChinaDepartment of Neurology, Taichung Veteran General Hospital, Taichung 40705, Taiwan, ChinaBackground. This study aimed to clarify whether Parkinson’s disease (PD) and depression were independent risk factors or with synergic effects in dementia. Methods. Newly diagnosed PD (n = 1213) patients and control subjects (n = 4852) were selected from the Taiwan National Health Insurance Research Database from January 2001 through December 2008. Follow-up ended in 2011 with an outcome of dementia occurring or not. This cohort was divided into controls with or without depression, PD only, and PD with depression. The incident rate of dementia and hazard ratio (HR) using Cox’s regression analysis were calculated for each group. Results. When compared with controls without depression as HR 1.00, the adjusted HR for dementia was 3.29 (p<0.001) in the PD only group, 2.77 (p<0.001) in the PD with depression group, and 1.55 (p=0.024) in the depression only group. The incident rate of dementia was 29.2 (per 1000 person-years) in the PD only group and 13.2 in the PD with depression group. The effect of PD on dementia in the depression group produced a HR of 0.97 (p=0.905). Conclusions. Parkinson’s disease served as a risk factor for dementia. By comparison, depression was not a risk factor for dementia in PD patients, although it did act as a risk factor for dementia.http://dx.doi.org/10.1155/2020/8493916 |
| spellingShingle | Ting-Chun Fang Yu-Hsuan Wu Yi-Huei Chen Ching-Heng Lin Ming-Hong Chang Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study Parkinson's Disease |
| title | Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study |
| title_full | Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study |
| title_fullStr | Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study |
| title_full_unstemmed | Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study |
| title_short | Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study |
| title_sort | risk of dementia in patients with depression or parkinson s disease a retrospective cohort study |
| url | http://dx.doi.org/10.1155/2020/8493916 |
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