Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.

Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.

Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a n...

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Main Authors: Adriana Rodríguez-Marí, Catherine Wilson, Tom A Titus, Cristian Cañestro, Ruth A BreMiller, Yi-Lin Yan, Indrajit Nanda, Adam Johnston, John P Kanki, Erin M Gray, Xinjun He, Jan Spitsbergen, Detlev Schindler, John H Postlethwait
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001357&type=printable
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