Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cells

Abstract Iron regulatory protein (IRP2) plays a key role in regulating iron metabolism and enables cell survival by activating mitochondrial function. Targeting IRP2 to disrupt iron homeostasis is a promising strategy for enhancing the efficacy of cancer treatments. Depletion of IRP2 in breast cance...

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Main Authors: Ye Yeong Jeong, Jieon Hwang, Areum Park, Sungmin Cho, Inyoung Cho, Soseul Won, You Me Shin, Sung Eun Kim, Chan Hoon Maeng, Jaemoon Yang, Minhee Ku, Hyuk Lee, Sang Joon Shin
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02653-z
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