The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis
Interleukin-6 (IL-6) has been shown to contribute to the progression of myocardial damage and dysfunction in congestive heart failure. We report a case of a 53-year old woman with congestive heart failure that may have been caused by IL-6 secreting uterine leiomyoma. The woman developed progressive...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5062 |
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| author | M. Ohta N. Keira S. Yoshida R. Yasuda Y. Tarumi H. Tsuchiya M. Kikai T. Nomura T. Tatsumi |
| author_facet | M. Ohta N. Keira S. Yoshida R. Yasuda Y. Tarumi H. Tsuchiya M. Kikai T. Nomura T. Tatsumi |
| author_sort | M. Ohta |
| collection | DOAJ |
| description | Interleukin-6 (IL-6) has been shown to contribute to the progression of myocardial damage and dysfunction in congestive heart failure. We report a case of a 53-year old woman with congestive heart failure that may have been caused by IL-6 secreting uterine leiomyoma. The woman developed progressive dyspnea, pleural effusion, and leg edema with a decreased left ventricular ejection fraction (LVEF). Imaging studies indicated uterine leiomyoma compressing the vena cava. Due to unresponsiveness to conventional medical treatment, she underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy to alleviate compression of the vena cava. After surgery, pleural effusion and leg edema completely resolved. Concomitant with the subsequent improvement of LVEF, a pre-operative serum IL-6 measurement of 36.2 pg/mL fell to 1.6 pg/mL postoperatively. Immunologically positive staining for IL-6 was demonstrated in the cytoplasm of most of the uterine leiomyoma cells. These findings suggest that IL-6 produced by leiomyoma cells may have been involved in the pathophysiological progression of heart failure and associated hemodynamic changes. |
| format | Article |
| id | doaj-art-7fa29f5af22d4053ad652c94cce20007 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-7fa29f5af22d4053ad652c94cce200072025-08-20T03:48:35ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147459059510.31083/j.ceog.2020.04.5062S0390-6663(20)00320-6The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosisM. Ohta0N. Keira1S. Yoshida2R. Yasuda3Y. Tarumi4H. Tsuchiya5M. Kikai6T. Nomura7T. Tatsumi8Department of Obstetrics and Gynecology, Chibune General Hospital, Osaka, JapanDepartment of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, JapanDepartment of Obstetrics and Gynecology, Chibune General Hospital, Osaka, JapanDepartment of Obstetrics and Gynecology, Chibune General Hospital, Osaka, JapanDepartment of Obstetrics and Gynecology, Kyoto Chubu Medical Center, Kyoto, JapanDepartment of Obstetrics and Gynecology, Kyoto Chubu Medical Center, Kyoto, JapanDepartment of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, JapanDepartment of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, JapanDepartment of Cardiovascular Medicine, Kyoto Chubu Medical Center, Kyoto, JapanInterleukin-6 (IL-6) has been shown to contribute to the progression of myocardial damage and dysfunction in congestive heart failure. We report a case of a 53-year old woman with congestive heart failure that may have been caused by IL-6 secreting uterine leiomyoma. The woman developed progressive dyspnea, pleural effusion, and leg edema with a decreased left ventricular ejection fraction (LVEF). Imaging studies indicated uterine leiomyoma compressing the vena cava. Due to unresponsiveness to conventional medical treatment, she underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy to alleviate compression of the vena cava. After surgery, pleural effusion and leg edema completely resolved. Concomitant with the subsequent improvement of LVEF, a pre-operative serum IL-6 measurement of 36.2 pg/mL fell to 1.6 pg/mL postoperatively. Immunologically positive staining for IL-6 was demonstrated in the cytoplasm of most of the uterine leiomyoma cells. These findings suggest that IL-6 produced by leiomyoma cells may have been involved in the pathophysiological progression of heart failure and associated hemodynamic changes.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5062leiomyomainterleukin-6heart failurepleural effusion |
| spellingShingle | M. Ohta N. Keira S. Yoshida R. Yasuda Y. Tarumi H. Tsuchiya M. Kikai T. Nomura T. Tatsumi The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis Clinical and Experimental Obstetrics & Gynecology leiomyoma interleukin-6 heart failure pleural effusion |
| title | The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| title_full | The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| title_fullStr | The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| title_full_unstemmed | The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| title_short | The possible involvement of interleukin-6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| title_sort | possible involvement of interleukin 6 in congestive heart failure in a postmenopausal woman with uterine fibromatosis |
| topic | leiomyoma interleukin-6 heart failure pleural effusion |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5062 |
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