A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche

A proinflammatory response and polarized differentiation of stromal elements characterizes the murine myeloma bone marrow niche

Abstract Background The bone marrow (BM) niche contains non-hematopoietic elements including mesenchymal stromal cells (MSC) and bone marrow endothelial cells (BMEC) which provide mechanical support, and control hematopoietic cell growth and differentiation. Although it is known that multiple myelom...

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Bibliographic Details
Main Authors: Hussein Ghamlouch, Dylan C. Gagler, Patrick Blaney, Eileen M. Boyle, Yubao Wang, Jason Avigan, Jinyoung Choi, Ola Landgren, Aristotelis Tsirigos, Francesco Maura, Gareth J. Morgan, Faith E. Davies
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Experimental Hematology & Oncology
Subjects:
Myeloma
Niche
Pro-inflammatory response
Bone marrow stress
Polarized differentiation
Mesenchymal stromal cells
Online Access:https://doi.org/10.1186/s40164-025-00606-x
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