Impact of EML4‐ALK Variants and TP53 Status on the Efficacy of ALK Inhibitors in Patients With Non‐small Cell Lung Cancer

Impact of EML4‐ALK Variants and TP53 Status on the Efficacy of ALK Inhibitors in Patients With Non‐small Cell Lung Cancer

ABSTRACT Background The clinical implications of different EML4‐ALK fusion variants remain poorly elucidated in the era of second‐generation ALK inhibitors. Methods This was a retrospective cohort study, wherein patients diagnosed with locally advanced or metastatic non‐small cell lung cancer harbor...

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Bibliographic Details
Main Authors: Zihua Zou, Lige Wu, Xuezhi Hao, Yan Li, Li Liang, Yangchun Gu, Jianming Ying, Junling Li, Puyuan Xing
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Thoracic Cancer
Subjects:
EML4‐ALK
NSCLC
TKI
TP53
Online Access:https://doi.org/10.1111/1759-7714.70000
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