Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins.
Cancer-associated thrombosis, a major cause of mortality in cancer patients, exhibits a 4 to 7 times higher incidence compared to the general population. Platelet activation by tumor cells contributes to this pro-thrombotic state. Cancer cell-educated platelets have also been described to be implica...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317096 |
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| _version_ | 1849327828938522624 |
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| author | Mélanie Langiu Lydie Crescence Diane Mège Christophe Dubois Laurence Panicot-Dubois |
| author_facet | Mélanie Langiu Lydie Crescence Diane Mège Christophe Dubois Laurence Panicot-Dubois |
| author_sort | Mélanie Langiu |
| collection | DOAJ |
| description | Cancer-associated thrombosis, a major cause of mortality in cancer patients, exhibits a 4 to 7 times higher incidence compared to the general population. Platelet activation by tumor cells contributes to this pro-thrombotic state. Cancer cell-educated platelets have also been described to be implicated in promoting metastasis. Intriguingly, our team, among others, unveils a reverse process, wherein platelets educate cancer cells by transferring lipids, RNAs, and proteins. Here, focusing on colorectal and pancreatic cancers, our study investigates genes and proteins mediating platelet education of cancer cells. We demonstrated, for the first time, that platelets can educate cancer cells by inducing changes in the transcription of genes related to glycosylation, inflammation, and metastasis in cancer cells themselves. These results indicate a direct impact of platelets on cancer cell phenotype. This novel insight suggests potential therapeutic avenues for cancer treatment, disrupting platelet-mediated alterations and influencing the course of cancer progression. |
| format | Article |
| id | doaj-art-7f98b6cd355e4893a3ed19074f6b8a20 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7f98b6cd355e4893a3ed19074f6b8a202025-08-20T03:47:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01203e031709610.1371/journal.pone.0317096Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins.Mélanie LangiuLydie CrescenceDiane MègeChristophe DuboisLaurence Panicot-DuboisCancer-associated thrombosis, a major cause of mortality in cancer patients, exhibits a 4 to 7 times higher incidence compared to the general population. Platelet activation by tumor cells contributes to this pro-thrombotic state. Cancer cell-educated platelets have also been described to be implicated in promoting metastasis. Intriguingly, our team, among others, unveils a reverse process, wherein platelets educate cancer cells by transferring lipids, RNAs, and proteins. Here, focusing on colorectal and pancreatic cancers, our study investigates genes and proteins mediating platelet education of cancer cells. We demonstrated, for the first time, that platelets can educate cancer cells by inducing changes in the transcription of genes related to glycosylation, inflammation, and metastasis in cancer cells themselves. These results indicate a direct impact of platelets on cancer cell phenotype. This novel insight suggests potential therapeutic avenues for cancer treatment, disrupting platelet-mediated alterations and influencing the course of cancer progression.https://doi.org/10.1371/journal.pone.0317096 |
| spellingShingle | Mélanie Langiu Lydie Crescence Diane Mège Christophe Dubois Laurence Panicot-Dubois Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. PLoS ONE |
| title | Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. |
| title_full | Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. |
| title_fullStr | Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. |
| title_full_unstemmed | Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. |
| title_short | Consequences of platelet-educated cancer cells on the expression of inflammatory and metastatic glycoproteins. |
| title_sort | consequences of platelet educated cancer cells on the expression of inflammatory and metastatic glycoproteins |
| url | https://doi.org/10.1371/journal.pone.0317096 |
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