Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict
Background: Methamphetamine (METH) is a potent synthetic stimulant that significantly impacts the central nervous system and can lead to severe liver damage. Prolonged METH use causes hepatocytes damage and fibrosis, marked by increased laminin deposition, a key component of the extracellular matri...
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College of Medicine University of Baghdad
2025-04-01
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| Series: | مجلة كلية الطب |
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| Online Access: | https://www.iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2477 |
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| author | Halla Gh. Mahmood Shahbaa W. Sami |
| author_facet | Halla Gh. Mahmood Shahbaa W. Sami |
| author_sort | Halla Gh. Mahmood |
| collection | DOAJ |
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Background: Methamphetamine (METH) is a potent synthetic stimulant that significantly impacts the central nervous system and can lead to severe liver damage. Prolonged METH use causes hepatocytes damage and fibrosis, marked by increased laminin deposition, a key component of the extracellular matrix produced by stellate cells during liver injury.
Objectives: This study aimed to investigate the effects of METH abuse on liver function and laminin (LN) levels, correlating these with the duration and concentration of METH use.
Methods: Conducted from January to August 2024, this case-control study involved 75 male participants with METH addiction (6-120 months of use) and 75 healthy controls aged 18-51. Key biomarkers were measured, including serum laminin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Gamma-Glutamyl Transferase (GGT), albumin and the serum concentration of methamphetamine levels.
Result: The study revealed a significant increase in serum laminin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and Gamma-Glutamyl Transferees. The notable significant decrease in albumin was detected. Additionally, the study demonstrated a positive correlation between LN levels and the duration of drug abuse, as between the concentration of methamphetamine levels with aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, Gamma-Glutamyl Transferees, and albumin, and correlation between methamphetamine of duration with aspartate aminotransferase, alanine aminotransferase, Gamma-Glutamyl Transferees.
Conclusions: The results indicate that METH addiction leads to elevated laminin levels and liver enzyme activity, suggesting progressive liver fibrosis and injury correlating with the duration of substance abuse.
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| format | Article |
| id | doaj-art-7f974dd2e76c4f57b86adbba46d08fcb |
| institution | DOAJ |
| issn | 0041-9419 2410-8057 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj-art-7f974dd2e76c4f57b86adbba46d08fcb2025-08-20T03:16:40ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572025-04-0167110.32007/jfacmedbaghdad2477Laminin Levels as a Biomarker for Liver injury in Methamphetamine AddictHalla Gh. Mahmood0https://orcid.org/0000-0002-7248-4409Shahbaa W. Sami1https://orcid.org/0009-0001-8092-1808Department of Chemistry, College of Medicine, University of Baghdad, Baghdad, Iraq.Ministry of Health, Baghdad, Iraq Background: Methamphetamine (METH) is a potent synthetic stimulant that significantly impacts the central nervous system and can lead to severe liver damage. Prolonged METH use causes hepatocytes damage and fibrosis, marked by increased laminin deposition, a key component of the extracellular matrix produced by stellate cells during liver injury. Objectives: This study aimed to investigate the effects of METH abuse on liver function and laminin (LN) levels, correlating these with the duration and concentration of METH use. Methods: Conducted from January to August 2024, this case-control study involved 75 male participants with METH addiction (6-120 months of use) and 75 healthy controls aged 18-51. Key biomarkers were measured, including serum laminin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Gamma-Glutamyl Transferase (GGT), albumin and the serum concentration of methamphetamine levels. Result: The study revealed a significant increase in serum laminin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and Gamma-Glutamyl Transferees. The notable significant decrease in albumin was detected. Additionally, the study demonstrated a positive correlation between LN levels and the duration of drug abuse, as between the concentration of methamphetamine levels with aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, Gamma-Glutamyl Transferees, and albumin, and correlation between methamphetamine of duration with aspartate aminotransferase, alanine aminotransferase, Gamma-Glutamyl Transferees. Conclusions: The results indicate that METH addiction leads to elevated laminin levels and liver enzyme activity, suggesting progressive liver fibrosis and injury correlating with the duration of substance abuse. https://www.iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2477Laminin; Liver function; Liver injury; Methamphetamine; Toxicity. |
| spellingShingle | Halla Gh. Mahmood Shahbaa W. Sami Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict مجلة كلية الطب Laminin; Liver function; Liver injury; Methamphetamine; Toxicity. |
| title | Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict |
| title_full | Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict |
| title_fullStr | Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict |
| title_full_unstemmed | Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict |
| title_short | Laminin Levels as a Biomarker for Liver injury in Methamphetamine Addict |
| title_sort | laminin levels as a biomarker for liver injury in methamphetamine addict |
| topic | Laminin; Liver function; Liver injury; Methamphetamine; Toxicity. |
| url | https://www.iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2477 |
| work_keys_str_mv | AT hallaghmahmood lamininlevelsasabiomarkerforliverinjuryinmethamphetamineaddict AT shahbaawsami lamininlevelsasabiomarkerforliverinjuryinmethamphetamineaddict |