Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study
ABSTRACT Background and Aim Managing benign biliary stricture endoscopically is complicated and challenging. This study aimed to evaluate the safety and efficacy of a 6‐month placement of a fully covered self‐expanding metallic stent for refractory benign biliary stricture. Methods Twenty‐two patien...
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Wiley
2025-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70103 |
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| author | Tomohisa Iwai Mitsuhiro Kida Kazuya Sugimori Hiroaki Shigoka Takaaki Matsumoto Masashi Ijima Haruo Miwa Kosuke Okuwaki Masafumi Watanabe Kai Adachi Akihiro Tamaki Taro Hanaoka Junro Ishizaki Chika Kusano |
| author_facet | Tomohisa Iwai Mitsuhiro Kida Kazuya Sugimori Hiroaki Shigoka Takaaki Matsumoto Masashi Ijima Haruo Miwa Kosuke Okuwaki Masafumi Watanabe Kai Adachi Akihiro Tamaki Taro Hanaoka Junro Ishizaki Chika Kusano |
| author_sort | Tomohisa Iwai |
| collection | DOAJ |
| description | ABSTRACT Background and Aim Managing benign biliary stricture endoscopically is complicated and challenging. This study aimed to evaluate the safety and efficacy of a 6‐month placement of a fully covered self‐expanding metallic stent for refractory benign biliary stricture. Methods Twenty‐two patients with refractory benign biliary stricture (13 with chronic pancreatitis and 9 without) were recruited from five higher tertiary care centers. All patients received a planned 6‐month fully covered self‐expanding metallic stent placement. Primary outcomes included clinical success, technical success of stent removal, adverse events, and stricture recurrence. Results Of the 21 cases (one case was excluded owing to malignant findings), fully covered self‐expanding metallic stent placement was successful in all cases, with contralateral bile duct plastic stents used in three patients and stents remaining in place for 6 months in 16 of 21 patients. Distal stent migration occurred in three cases, two of which had resolved strictures. Adverse events were observed in 19.0% of patients: one case of severe cholangitis, two cases of mild cholangitis, and one case of hyperplasia formation. No stent‐induced pancreatitis or cholecystitis occurred. All stents were removed successfully, and the treatment success rate was 85%. One patient experienced recurrent stricture 6.5 months post‐stent removal. Conclusions A six‐month placement of a modified fully covered self‐expanding metallic stent effectively improved strictures and minimized stent‐induced Adverse events in patients with refractory benign biliary stricture. Trial Registration UMIN ID: UMIN000025027 |
| format | Article |
| id | doaj-art-7f97268f93824de29581c7bff550301f |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj-art-7f97268f93824de29581c7bff550301f2025-01-28T09:24:32ZengWileyJGH Open2397-90702025-01-0191n/an/a10.1002/jgh3.70103Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective StudyTomohisa Iwai0Mitsuhiro Kida1Kazuya Sugimori2Hiroaki Shigoka3Takaaki Matsumoto4Masashi Ijima5Haruo Miwa6Kosuke Okuwaki7Masafumi Watanabe8Kai Adachi9Akihiro Tamaki10Taro Hanaoka11Junro Ishizaki12Chika Kusano13Department of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Yokohama City University Medical Center Yokohama JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine Toho University Ohashi Medical Center Setagaya JapanDepartment of Gastroenterology Isehara Kyodo Hospital Isehara JapanDepartment of Gastroenterology Subaru Health Insurance Society Ota Memorial Hospital Ota JapanDepartment of Gastroenterology Yokohama City University Medical Center Yokohama JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanDepartment of Gastroenterology Kitasato University School of Medicine Sagamihara JapanABSTRACT Background and Aim Managing benign biliary stricture endoscopically is complicated and challenging. This study aimed to evaluate the safety and efficacy of a 6‐month placement of a fully covered self‐expanding metallic stent for refractory benign biliary stricture. Methods Twenty‐two patients with refractory benign biliary stricture (13 with chronic pancreatitis and 9 without) were recruited from five higher tertiary care centers. All patients received a planned 6‐month fully covered self‐expanding metallic stent placement. Primary outcomes included clinical success, technical success of stent removal, adverse events, and stricture recurrence. Results Of the 21 cases (one case was excluded owing to malignant findings), fully covered self‐expanding metallic stent placement was successful in all cases, with contralateral bile duct plastic stents used in three patients and stents remaining in place for 6 months in 16 of 21 patients. Distal stent migration occurred in three cases, two of which had resolved strictures. Adverse events were observed in 19.0% of patients: one case of severe cholangitis, two cases of mild cholangitis, and one case of hyperplasia formation. No stent‐induced pancreatitis or cholecystitis occurred. All stents were removed successfully, and the treatment success rate was 85%. One patient experienced recurrent stricture 6.5 months post‐stent removal. Conclusions A six‐month placement of a modified fully covered self‐expanding metallic stent effectively improved strictures and minimized stent‐induced Adverse events in patients with refractory benign biliary stricture. Trial Registration UMIN ID: UMIN000025027https://doi.org/10.1002/jgh3.70103benign biliary stricturechronic pancreatitisfully covered self‐expanding metallic stent |
| spellingShingle | Tomohisa Iwai Mitsuhiro Kida Kazuya Sugimori Hiroaki Shigoka Takaaki Matsumoto Masashi Ijima Haruo Miwa Kosuke Okuwaki Masafumi Watanabe Kai Adachi Akihiro Tamaki Taro Hanaoka Junro Ishizaki Chika Kusano Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study JGH Open benign biliary stricture chronic pancreatitis fully covered self‐expanding metallic stent |
| title | Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study |
| title_full | Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study |
| title_fullStr | Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study |
| title_full_unstemmed | Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study |
| title_short | Safety and Efficacy of a 6‐Month Placement of a Fully Covered Self‐Expanding Metallic Stent for Refractory Benign Biliary Stricture: A Multicenter Prospective Study |
| title_sort | safety and efficacy of a 6 month placement of a fully covered self expanding metallic stent for refractory benign biliary stricture a multicenter prospective study |
| topic | benign biliary stricture chronic pancreatitis fully covered self‐expanding metallic stent |
| url | https://doi.org/10.1002/jgh3.70103 |
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