Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication
Abstract Malaria remains a significant public health challenge, particularly in low- and middle-income countries, despite ongoing efforts to eradicate the disease. Recent advancements, including the rollout of malaria vaccines, such as RTS,S/AS01 and R21/Matrix-M™, offer new avenues for prevention....
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-025-05243-7 |
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| author | Israel Charles Abraham John Ehi Aboje Bonaventure Michael Ukoaka Kehinde Tom-Ayegunle Maryam Amjad Anas Abdulkader Chinonyelum Emmanuel Agbo Oluwatosin Ayokunle Akinruli Taiwo Rebecca Akisanmi Emmanuel Oyedeji Oyetola Gbolahan Olatunji Emmanuel Kokori Nicholas Aderinto |
| author_facet | Israel Charles Abraham John Ehi Aboje Bonaventure Michael Ukoaka Kehinde Tom-Ayegunle Maryam Amjad Anas Abdulkader Chinonyelum Emmanuel Agbo Oluwatosin Ayokunle Akinruli Taiwo Rebecca Akisanmi Emmanuel Oyedeji Oyetola Gbolahan Olatunji Emmanuel Kokori Nicholas Aderinto |
| author_sort | Israel Charles Abraham |
| collection | DOAJ |
| description | Abstract Malaria remains a significant public health challenge, particularly in low- and middle-income countries, despite ongoing efforts to eradicate the disease. Recent advancements, including the rollout of malaria vaccines, such as RTS,S/AS01 and R21/Matrix-M™, offer new avenues for prevention. However, the rise of resistance to anti-malarial medications necessitates innovative strategies. This review explores the potential integration of CRISPR/Cas9 gene drive technology with malaria vaccination efforts to enhance vector control and reduce transmission. By employing gene drive mechanisms for population suppression and replacement of malaria-transmitting Anopheles mosquitoes, combined with the immunogenic properties of vaccines, a synergistic approach can be established. This paper discussed the need for integrated strategies to address the biological complexities of malaria and socio-economic factors influencing its prevalence. Challenges such as regulatory hurdles, community acceptance, ecological impacts, and sustainable funding are examined, alongside strategies for implementation within existing malaria control programmes. This integrated approach could significantly contribute to achieving the World Health Organization's targets for malaria reduction by 2030, ultimately enhancing public health outcomes and supporting broader socio-economic development. |
| format | Article |
| id | doaj-art-7f9187aa23784040bf5285f55122435d |
| institution | Kabale University |
| issn | 1475-2875 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj-art-7f9187aa23784040bf5285f55122435d2025-01-19T12:11:09ZengBMCMalaria Journal1475-28752025-01-012411710.1186/s12936-025-05243-7Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradicationIsrael Charles Abraham0John Ehi Aboje1Bonaventure Michael Ukoaka2Kehinde Tom-Ayegunle3Maryam Amjad4Anas Abdulkader5Chinonyelum Emmanuel Agbo6Oluwatosin Ayokunle Akinruli7Taiwo Rebecca Akisanmi8Emmanuel Oyedeji Oyetola9Gbolahan Olatunji10Emmanuel Kokori11Nicholas Aderinto12Department of Medicine and Surgery, University of IlorinBenue State University, College of Health SciencesDepartment of Internal Medicine, Asokoro District HospitalDept of Epidemiology & Biostatistics, Johns Hopkins Bloomberg School of Public HealthLiaquat National Hospital and Medical College KarachiCollege of Medicine, AlMaarefa UniversityDepartment of Pharmaceutical Sciences, University of NigeriaNational Health ServiceDepartment of Internal Medicine, State Hospital AbeokutaDepartment of Medicine, Ladoke Akintola University of TechnologyDepartment of Medicine and Surgery, University of IlorinDepartment of Medicine and Surgery, University of IlorinDepartment of Medicine, Ladoke Akintola University of TechnologyAbstract Malaria remains a significant public health challenge, particularly in low- and middle-income countries, despite ongoing efforts to eradicate the disease. Recent advancements, including the rollout of malaria vaccines, such as RTS,S/AS01 and R21/Matrix-M™, offer new avenues for prevention. However, the rise of resistance to anti-malarial medications necessitates innovative strategies. This review explores the potential integration of CRISPR/Cas9 gene drive technology with malaria vaccination efforts to enhance vector control and reduce transmission. By employing gene drive mechanisms for population suppression and replacement of malaria-transmitting Anopheles mosquitoes, combined with the immunogenic properties of vaccines, a synergistic approach can be established. This paper discussed the need for integrated strategies to address the biological complexities of malaria and socio-economic factors influencing its prevalence. Challenges such as regulatory hurdles, community acceptance, ecological impacts, and sustainable funding are examined, alongside strategies for implementation within existing malaria control programmes. This integrated approach could significantly contribute to achieving the World Health Organization's targets for malaria reduction by 2030, ultimately enhancing public health outcomes and supporting broader socio-economic development.https://doi.org/10.1186/s12936-025-05243-7MalariaVaccineCRISPR/Cas9Gene drive technology |
| spellingShingle | Israel Charles Abraham John Ehi Aboje Bonaventure Michael Ukoaka Kehinde Tom-Ayegunle Maryam Amjad Anas Abdulkader Chinonyelum Emmanuel Agbo Oluwatosin Ayokunle Akinruli Taiwo Rebecca Akisanmi Emmanuel Oyedeji Oyetola Gbolahan Olatunji Emmanuel Kokori Nicholas Aderinto Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication Malaria Journal Malaria Vaccine CRISPR/Cas9 Gene drive technology |
| title | Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication |
| title_full | Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication |
| title_fullStr | Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication |
| title_full_unstemmed | Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication |
| title_short | Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication |
| title_sort | integrating malaria vaccine and crispr cas9 gene drive a comprehensive strategy for accelerated malaria eradication |
| topic | Malaria Vaccine CRISPR/Cas9 Gene drive technology |
| url | https://doi.org/10.1186/s12936-025-05243-7 |
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