Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease
Abstract Excretion of sodium and water through the skin as sweat represents a regulatory mechanism of electrolyte- and fluid balance. Since patients with chronic kidney disease (CKD) exhibit increased skin sodium content, we investigated the feasibility of sweat testing as a novel experimental tool...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-05855-8 |
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| author | Tarik Shoumariyeh Florian Logar Oliver Helk Johannes Hofer Klaus G. Schmetterer Brigitte Mersi Saskia Gruber Marcus D. Säemann Christopher C. Kaltenecker Johannes J. Kovarik |
| author_facet | Tarik Shoumariyeh Florian Logar Oliver Helk Johannes Hofer Klaus G. Schmetterer Brigitte Mersi Saskia Gruber Marcus D. Säemann Christopher C. Kaltenecker Johannes J. Kovarik |
| author_sort | Tarik Shoumariyeh |
| collection | DOAJ |
| description | Abstract Excretion of sodium and water through the skin as sweat represents a regulatory mechanism of electrolyte- and fluid balance. Since patients with chronic kidney disease (CKD) exhibit increased skin sodium content, we investigated the feasibility of sweat testing as a novel experimental tool to provide a more complete assessment of fluid- and sodium status. In this cross-sectional feasibility study, we applied pilocarpine iontophoresis to induce sweat testing in 58 patients across various stages of CKD including kidney transplant recipients and a healthy control cohort (n = 6) to investigate possible effects of CKD and transplantation status on sweat weight and sodium concentration. Due to non-linear relationships, we modeled our data using polynomial regression. Decline of kidney function showed a significant association with lower sweat weight: adj R2 = 0.2278, F(2, 61) = 10.29, p = 0.0001. Sweat sodium concentrations were increased in moderate CKD, however, this effect was lost in end-stage kidney disease with and without requirement of hemodialysis: adj R2 = 0.3701, F(4, 59) = 10.26, p = 2.261e-06. Diagnostic sweat analysis represents an innovative, non-invasive option for a more thorough investigation of sodium- and fluid homeostasis in CKD. Lower sweat weight and higher sweat sodium concentrations represent a unique feature of CKD patients with potential therapeutic implications. Trial registration: This study is registered at ClinTrials.gov with the study number NCT06354842. |
| format | Article |
| id | doaj-art-7f91326ebaf54ffeba355a7e0b986728 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7f91326ebaf54ffeba355a7e0b9867282025-08-20T03:45:27ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-05855-8Decline of kidney function is associated with lower sweat weight in patients with chronic kidney diseaseTarik Shoumariyeh0Florian Logar1Oliver Helk2Johannes Hofer3Klaus G. Schmetterer4Brigitte Mersi5Saskia Gruber6Marcus D. Säemann7Christopher C. Kaltenecker8Johannes J. Kovarik9Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, General Hospital of ViennaDepartment of Ophthalmology, Academic Teaching Hospital of St. John of GodDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, General Hospital of ViennaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, General Hospital of ViennaDepartment of Laboratory Medicine, Medical University of Vienna, General Hospital of ViennaDepartment of Pediatric and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, General Hospital of ViennaDepartment of Pediatric and Adolescent Medicine, Division of Pediatric Pulmonology, Allergology and Endocrinology, Medical University of Vienna, General Hospital of Vienna6th Medical Department with Nephrology and Dialysis, Clinic OttakringDepartment of Pathology, Medical University of Vienna, General Hospital of ViennaDepartment of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, General Hospital of ViennaAbstract Excretion of sodium and water through the skin as sweat represents a regulatory mechanism of electrolyte- and fluid balance. Since patients with chronic kidney disease (CKD) exhibit increased skin sodium content, we investigated the feasibility of sweat testing as a novel experimental tool to provide a more complete assessment of fluid- and sodium status. In this cross-sectional feasibility study, we applied pilocarpine iontophoresis to induce sweat testing in 58 patients across various stages of CKD including kidney transplant recipients and a healthy control cohort (n = 6) to investigate possible effects of CKD and transplantation status on sweat weight and sodium concentration. Due to non-linear relationships, we modeled our data using polynomial regression. Decline of kidney function showed a significant association with lower sweat weight: adj R2 = 0.2278, F(2, 61) = 10.29, p = 0.0001. Sweat sodium concentrations were increased in moderate CKD, however, this effect was lost in end-stage kidney disease with and without requirement of hemodialysis: adj R2 = 0.3701, F(4, 59) = 10.26, p = 2.261e-06. Diagnostic sweat analysis represents an innovative, non-invasive option for a more thorough investigation of sodium- and fluid homeostasis in CKD. Lower sweat weight and higher sweat sodium concentrations represent a unique feature of CKD patients with potential therapeutic implications. Trial registration: This study is registered at ClinTrials.gov with the study number NCT06354842.https://doi.org/10.1038/s41598-025-05855-8 |
| spellingShingle | Tarik Shoumariyeh Florian Logar Oliver Helk Johannes Hofer Klaus G. Schmetterer Brigitte Mersi Saskia Gruber Marcus D. Säemann Christopher C. Kaltenecker Johannes J. Kovarik Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease Scientific Reports |
| title | Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| title_full | Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| title_fullStr | Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| title_full_unstemmed | Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| title_short | Decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| title_sort | decline of kidney function is associated with lower sweat weight in patients with chronic kidney disease |
| url | https://doi.org/10.1038/s41598-025-05855-8 |
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