Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report
Abstract Background Outcome of the liver transplantation (LT) is worse in hepatitis C virus (HCV)/human immunodeficiency virus (HIV)-coinfected patients compared to patients infected with HCV alone. We report the world’s first case of living donor domino liver transplantation (LDDLT) using a familia...
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| Format: | Article |
| Language: | English |
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Japan Surgical Society
2020-07-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00944-4 |
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| author | Hidekazu Yamamoto Yasuhiko Sugawara Yuzuru Sambommatsu Keita Shimata Daiki Yoshii Kaori Isono Masaki Honda Taro Yamashita Shuzo Matsushita Yukihiro Inomata Taizo Hibi |
| author_facet | Hidekazu Yamamoto Yasuhiko Sugawara Yuzuru Sambommatsu Keita Shimata Daiki Yoshii Kaori Isono Masaki Honda Taro Yamashita Shuzo Matsushita Yukihiro Inomata Taizo Hibi |
| author_sort | Hidekazu Yamamoto |
| collection | DOAJ |
| description | Abstract Background Outcome of the liver transplantation (LT) is worse in hepatitis C virus (HCV)/human immunodeficiency virus (HIV)-coinfected patients compared to patients infected with HCV alone. We report the world’s first case of living donor domino liver transplantation (LDDLT) using a familial amyloid polyneuropathy (FAP) liver in a coinfected recipient with HCV-related liver cirrhosis. Case presentation The recipient was a 43-year-old male with a CD4 cell count of 52/μL and undetectable HIV-RNA at the time of LT. He received a domino liver graft from a 41-year-old female with FAP. No acute cellular rejection or infection occurred after LT. HCV recurrence was confirmed histologically on the posttransplant day 34. Peginterferon/ribavirin therapy resulted in non-response; however, the patient achieved a sustained viral response with sofosbuvir (SOF)/ledipasvir (LDV). Currently, HCV and HIV testing are negative, and symptomatic de novo amyloidosis has not occurred. Conclusions LDDLT allows successful LT in HCV/HIV-coinfected patients; posttransplant HCV recurrence can be successfully treated with anti-viral therapy. |
| format | Article |
| id | doaj-art-7f8a0da242d240768bb9b479f5d443b9 |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-7f8a0da242d240768bb9b479f5d443b92025-08-20T03:14:58ZengJapan Surgical SocietySurgical Case Reports2198-77932020-07-01611510.1186/s40792-020-00944-4Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case reportHidekazu Yamamoto0Yasuhiko Sugawara1Yuzuru Sambommatsu2Keita Shimata3Daiki Yoshii4Kaori Isono5Masaki Honda6Taro Yamashita7Shuzo Matsushita8Yukihiro Inomata9Taizo Hibi10Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesDepartment of Neurology, Kumamoto University Graduate School of Medical SciencesCenter for AIDS Research, Kumamoto UniversityDepartment of Surgery, Kumamoto Rosai HospitalDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical SciencesAbstract Background Outcome of the liver transplantation (LT) is worse in hepatitis C virus (HCV)/human immunodeficiency virus (HIV)-coinfected patients compared to patients infected with HCV alone. We report the world’s first case of living donor domino liver transplantation (LDDLT) using a familial amyloid polyneuropathy (FAP) liver in a coinfected recipient with HCV-related liver cirrhosis. Case presentation The recipient was a 43-year-old male with a CD4 cell count of 52/μL and undetectable HIV-RNA at the time of LT. He received a domino liver graft from a 41-year-old female with FAP. No acute cellular rejection or infection occurred after LT. HCV recurrence was confirmed histologically on the posttransplant day 34. Peginterferon/ribavirin therapy resulted in non-response; however, the patient achieved a sustained viral response with sofosbuvir (SOF)/ledipasvir (LDV). Currently, HCV and HIV testing are negative, and symptomatic de novo amyloidosis has not occurred. Conclusions LDDLT allows successful LT in HCV/HIV-coinfected patients; posttransplant HCV recurrence can be successfully treated with anti-viral therapy.http://link.springer.com/article/10.1186/s40792-020-00944-4Direct-acting antiviralsHCV/HIV-coinfectionLiver transplantationLiving donor domino liver transplantationSofosbuvir/ledipasvir |
| spellingShingle | Hidekazu Yamamoto Yasuhiko Sugawara Yuzuru Sambommatsu Keita Shimata Daiki Yoshii Kaori Isono Masaki Honda Taro Yamashita Shuzo Matsushita Yukihiro Inomata Taizo Hibi Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report Surgical Case Reports Direct-acting antivirals HCV/HIV-coinfection Liver transplantation Living donor domino liver transplantation Sofosbuvir/ledipasvir |
| title | Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report |
| title_full | Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report |
| title_fullStr | Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report |
| title_full_unstemmed | Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report |
| title_short | Living donor domino liver transplantation in a hepatitis C virus/human immunodeficiency virus-coinfected hemophilia patient: a case report |
| title_sort | living donor domino liver transplantation in a hepatitis c virus human immunodeficiency virus coinfected hemophilia patient a case report |
| topic | Direct-acting antivirals HCV/HIV-coinfection Liver transplantation Living donor domino liver transplantation Sofosbuvir/ledipasvir |
| url | http://link.springer.com/article/10.1186/s40792-020-00944-4 |
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