Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study
Objective: We estimated the influenza vaccination effectiveness (IVE) in preventing medical consultations and hospitalizations due to influenza during the 2023/24 season. Methods: Two test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224004399 |
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| author | Iván Martínez-Baz Ana Navascués Camino Trobajo-Sanmartín Francisco Pozo Miguel Fernández-Huerta Maddi Olazabal-Arruiz Lucía Argente-Colas Guillermo Ezpeleta Aitziber Echeverria Itziar Casado Carmen Ezpeleta Jesús Castilla |
| author_facet | Iván Martínez-Baz Ana Navascués Camino Trobajo-Sanmartín Francisco Pozo Miguel Fernández-Huerta Maddi Olazabal-Arruiz Lucía Argente-Colas Guillermo Ezpeleta Aitziber Echeverria Itziar Casado Carmen Ezpeleta Jesús Castilla |
| author_sort | Iván Martínez-Baz |
| collection | DOAJ |
| description | Objective: We estimated the influenza vaccination effectiveness (IVE) in preventing medical consultations and hospitalizations due to influenza during the 2023/24 season. Methods: Two test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respiratory symptoms and were tested for influenza by PCR in the 2023/24 season in Navarre, Spain. Influenza vaccination status in the current and previous seasons was compared between confirmed influenza cases and test-negative controls. IVE was calculated as (1-adjusted odds ratio)×100. Results: Of 3133 hospitalized patients, 529 (17%) were positive for influenza: 71% A/H1N1, 23% A/H3N2, and 7% A nonsubtyped. IVE to prevent hospitalizations was 43% (95%CI: 26%, 56%) overall, 61% (95%CI: 32%, 77%) in people younger than 65 years old and 35% (95%CI: 10%, 53%) in older people. IVE was 48% (95%CI: 30%, 61%) against influenza A/H1N1, and 15% (95%CI: -42%, 49%) against influenza A/H3N2. IVE in people vaccinated only in the previous season was 28% (95%CI: -5%, 51%). Among 417 outpatients, 146 (35%) were confirmed for influenza. IVE to prevent outpatient cases was 49% (95%CI: -9%, 76%) overall and 42% (95%CI: -33%, 74%) against influenza A/H1N1. Conclusions: IVE was moderate against influenza A/H1N1 and low against influenza A/H3N2 in the 2023/24 season. |
| format | Article |
| id | doaj-art-7f81b1f3ca0b4a199e2c4935f1db9a66 |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-7f81b1f3ca0b4a199e2c4935f1db9a662025-01-05T04:27:51ZengElsevierInternational Journal of Infectious Diseases1201-97122025-02-01151107364Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control studyIván Martínez-Baz0Ana Navascués1Camino Trobajo-Sanmartín2Francisco Pozo3Miguel Fernández-Huerta4Maddi Olazabal-Arruiz5Lucía Argente-Colas6Guillermo Ezpeleta7Aitziber Echeverria8Itziar Casado9Carmen Ezpeleta10Jesús Castilla11Instituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Corresponding author: Iván Martínez-Baz, Instituto de Salud Pública de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, SpainInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, SpainInstituto de Salud Pública de Navarra, Pamplona, SpainInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Clinical Microbiology Department, Hospital Universitario de Navarra, Pamplona, SpainInstituto de Salud Pública de Navarra, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainObjective: We estimated the influenza vaccination effectiveness (IVE) in preventing medical consultations and hospitalizations due to influenza during the 2023/24 season. Methods: Two test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respiratory symptoms and were tested for influenza by PCR in the 2023/24 season in Navarre, Spain. Influenza vaccination status in the current and previous seasons was compared between confirmed influenza cases and test-negative controls. IVE was calculated as (1-adjusted odds ratio)×100. Results: Of 3133 hospitalized patients, 529 (17%) were positive for influenza: 71% A/H1N1, 23% A/H3N2, and 7% A nonsubtyped. IVE to prevent hospitalizations was 43% (95%CI: 26%, 56%) overall, 61% (95%CI: 32%, 77%) in people younger than 65 years old and 35% (95%CI: 10%, 53%) in older people. IVE was 48% (95%CI: 30%, 61%) against influenza A/H1N1, and 15% (95%CI: -42%, 49%) against influenza A/H3N2. IVE in people vaccinated only in the previous season was 28% (95%CI: -5%, 51%). Among 417 outpatients, 146 (35%) were confirmed for influenza. IVE to prevent outpatient cases was 49% (95%CI: -9%, 76%) overall and 42% (95%CI: -33%, 74%) against influenza A/H1N1. Conclusions: IVE was moderate against influenza A/H1N1 and low against influenza A/H3N2 in the 2023/24 season.http://www.sciencedirect.com/science/article/pii/S1201971224004399Influenzainfluenza vaccinecase-control studyvaccine effectivenessprevious vaccination |
| spellingShingle | Iván Martínez-Baz Ana Navascués Camino Trobajo-Sanmartín Francisco Pozo Miguel Fernández-Huerta Maddi Olazabal-Arruiz Lucía Argente-Colas Guillermo Ezpeleta Aitziber Echeverria Itziar Casado Carmen Ezpeleta Jesús Castilla Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study International Journal of Infectious Diseases Influenza influenza vaccine case-control study vaccine effectiveness previous vaccination |
| title | Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study |
| title_full | Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study |
| title_fullStr | Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study |
| title_full_unstemmed | Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study |
| title_short | Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study |
| title_sort | effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in northern spain 2023 24 season a population based test negative case control study |
| topic | Influenza influenza vaccine case-control study vaccine effectiveness previous vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224004399 |
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