Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation
Background: This study aims to evaluate the effectiveness of manual lymphatic drainage (MLD) combined with abdominal breathing in rehabilitating postpartum perineal oedema and Serum IL-6, IL-10, TNF-a. Methods: A total of 172 primiparous women who delivered in our hospital between January 2022 and J...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504831X.pdf |
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| author | Xue Lili Jiang Yaqiong Guo Yongli Ma Hongyan Jiang Lingling Wang Xiaoyu Kang Xinyi Wang Ying Cao Jiachen Chen Liping |
| author_facet | Xue Lili Jiang Yaqiong Guo Yongli Ma Hongyan Jiang Lingling Wang Xiaoyu Kang Xinyi Wang Ying Cao Jiachen Chen Liping |
| author_sort | Xue Lili |
| collection | DOAJ |
| description | Background: This study aims to evaluate the effectiveness of manual lymphatic drainage (MLD) combined with abdominal breathing in rehabilitating postpartum perineal oedema and Serum IL-6, IL-10, TNF-a. Methods: A total of 172 primiparous women who delivered in our hospital between January 2022 and June 2023 were randomly assigned to either the observation group (n=86) or the control group (n=86). The control group received routine midwifery care, while the observation group received additional MLD and abdominal breathing training. Outcomes measured included pain levels, induration diameter, comfort, emotional state, recovery time, and clinical efficacy. Inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumour necrosis factor-alpha (TNF-a), were also assessed. Results: Both groups demonstrated significant reductions in Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores after treatment (P<0.05), with the observation group showing a greater decrease (P<0.05). The observation group exhibited a significantly shorter recovery time (3.6±1.8 days vs. 4.2±2.5 days, P<0.05) and reported higher comfort levels and lower pain scores than the control group (P<0.05). The effective treatment rate was 97.68% in the observation group, significantly higher than the 82.56% observed in the control group (P<0.05). Inflammatory markers, including IL-6 and TNF-a, showed a significant reduction in the observation group. Conclusions: Combining MLD and abdominal breathing reduces postpartum perineal oedema effectively, alleviates pain, and enhances recovery. It also lowers inflammatory markers (IL-6, TNF-a) and increases IL-10, promoting faster healing and improved maternal comfort. |
| format | Article |
| id | doaj-art-7f7e3f05922347ae8b8ce14fb0ce4503 |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-7f7e3f05922347ae8b8ce14fb0ce45032025-08-20T03:29:44ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144483183910.5937/jomb0-565991452-82582504831XSerum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitationXue Lili0Jiang Yaqiong1Guo Yongli2Ma Hongyan3Jiang Lingling4Wang Xiaoyu5Kang Xinyi6Wang Ying7Cao Jiachen8Chen Liping9Affiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaAffiliated Hospital 2 of Nantong University, Department of Obstetrics and Gynecology, Nantong First People's Hospital, Nantong, Jiangsu, ChinaBackground: This study aims to evaluate the effectiveness of manual lymphatic drainage (MLD) combined with abdominal breathing in rehabilitating postpartum perineal oedema and Serum IL-6, IL-10, TNF-a. Methods: A total of 172 primiparous women who delivered in our hospital between January 2022 and June 2023 were randomly assigned to either the observation group (n=86) or the control group (n=86). The control group received routine midwifery care, while the observation group received additional MLD and abdominal breathing training. Outcomes measured included pain levels, induration diameter, comfort, emotional state, recovery time, and clinical efficacy. Inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumour necrosis factor-alpha (TNF-a), were also assessed. Results: Both groups demonstrated significant reductions in Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores after treatment (P<0.05), with the observation group showing a greater decrease (P<0.05). The observation group exhibited a significantly shorter recovery time (3.6±1.8 days vs. 4.2±2.5 days, P<0.05) and reported higher comfort levels and lower pain scores than the control group (P<0.05). The effective treatment rate was 97.68% in the observation group, significantly higher than the 82.56% observed in the control group (P<0.05). Inflammatory markers, including IL-6 and TNF-a, showed a significant reduction in the observation group. Conclusions: Combining MLD and abdominal breathing reduces postpartum perineal oedema effectively, alleviates pain, and enhances recovery. It also lowers inflammatory markers (IL-6, TNF-a) and increases IL-10, promoting faster healing and improved maternal comfort.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504831X.pdfcrpesril-6il-10tnf-anatural childbirthperineal oedemamanual lymphatic drainageabdominal breathingpostpartum recovery |
| spellingShingle | Xue Lili Jiang Yaqiong Guo Yongli Ma Hongyan Jiang Lingling Wang Xiaoyu Kang Xinyi Wang Ying Cao Jiachen Chen Liping Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation Journal of Medical Biochemistry crp esr il-6 il-10 tnf-a natural childbirth perineal oedema manual lymphatic drainage abdominal breathing postpartum recovery |
| title | Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation |
| title_full | Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation |
| title_fullStr | Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation |
| title_full_unstemmed | Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation |
| title_short | Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation |
| title_sort | serum il 6 il 10 tnf a changes in postpartum perineal oedema rehabilitation |
| topic | crp esr il-6 il-10 tnf-a natural childbirth perineal oedema manual lymphatic drainage abdominal breathing postpartum recovery |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582504831X.pdf |
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