Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder
BackgroundIt has been widely demonstrated that siblings of children with autism spectrum disorder (ASD) have an increased risk of abnormal developmental trajectories. In response to this, early recognition protocols have been developed worldwide, aiming to promote early interventions that can positi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1467783/full |
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| author | Silvia Annunziata Giulia Purpura Giulia Purpura Elena Piazza Paolo Meriggi Gabriele Fassina Laura Santos Emilia Ambrosini Antonella Marchetti Antonella Marchetti Federico Manzi Federico Manzi Davide Massaro Davide Massaro Andrea Luna Tacci Andrea Luna Tacci Elisabetta Bolognesi Simone Agostini Francesca La Rosa Alessandra Paola Giulia Pedrocchi Paola Molina Anna Cavallini |
| author_facet | Silvia Annunziata Giulia Purpura Giulia Purpura Elena Piazza Paolo Meriggi Gabriele Fassina Laura Santos Emilia Ambrosini Antonella Marchetti Antonella Marchetti Federico Manzi Federico Manzi Davide Massaro Davide Massaro Andrea Luna Tacci Andrea Luna Tacci Elisabetta Bolognesi Simone Agostini Francesca La Rosa Alessandra Paola Giulia Pedrocchi Paola Molina Anna Cavallini |
| author_sort | Silvia Annunziata |
| collection | DOAJ |
| description | BackgroundIt has been widely demonstrated that siblings of children with autism spectrum disorder (ASD) have an increased risk of abnormal developmental trajectories. In response to this, early recognition protocols have been developed worldwide, aiming to promote early interventions that can positively impact the neurodevelopment of this population. This paper presents the protocol of a controlled trial: ERI-SIBS (Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders) is an innovative and ecological early recognition and intervention program designed specifically for siblings of children with ASD.MethodsWe aim to recruit siblings at low risk and high risk of neurodevelopmental disorders. Based on clinical evaluation at T0, we will allocate the infants into three groups: Group 1, infants at low risk without any signs of neurodevelopmental disorders; Group 2, infants at high risk without any signs of neurodevelopmental disorders; Group 3: infants at low or high risk with signs suggestive of neurodevelopmental disorders. Children of Group 2 will undergo Active Monitoring (one 90 min session once a month for 6 months), while children of Group 3 will undergo Early Intervention (one 90 min session once a week for 6 months). In both cases, the ERI-SIBS contents are based on a multidimensional and naturalistic approach and always involve caregivers. All recruited children will be evaluated at three different time points (T0 within the 8 months of life of the child, T1 after 6 months and T2 after 12 months) using behavioural, technological, and biological techniques to assess infants’ neurodevelopmental functions, parent-infant interaction, and early ASD markers.DiscussionThe ERI-SIBS study will expand knowledge regarding the impact of early intervention on families of infants at risk of neurodevelopmental disorders for the presence of a child with a diagnosis of ASD. The study will have the potential to significantly contribute to future research and the scientific and clinical debate on the best way to implement early intervention in at-risk populations.
Clinical Trial RegistrationClinicaltrials.gov identifier (NCT06512649). |
| format | Article |
| id | doaj-art-7f7d40b86a4d4af6828162acf373fe09 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-7f7d40b86a4d4af6828162acf373fe092025-01-06T06:59:43ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14677831467783Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorderSilvia Annunziata0Giulia Purpura1Giulia Purpura2Elena Piazza3Paolo Meriggi4Gabriele Fassina5Laura Santos6Emilia Ambrosini7Antonella Marchetti8Antonella Marchetti9Federico Manzi10Federico Manzi11Davide Massaro12Davide Massaro13Andrea Luna Tacci14Andrea Luna Tacci15Elisabetta Bolognesi16Simone Agostini17Francesca La Rosa18Alessandra Paola Giulia Pedrocchi19Paola Molina20Anna Cavallini21IRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalySchool of Medicine and Surgery, University of Milano Bicocca, Monza, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyUniToM, Università Cattolica del Sacro Cuore, Milano, ItalyDepartment of Psychology, Università Cattolica del Sacro Cuore, Milano, ItalyUniToM, Università Cattolica del Sacro Cuore, Milano, ItalyDepartment of Psychology, Università Cattolica del Sacro Cuore, Milano, ItalyUniToM, Università Cattolica del Sacro Cuore, Milano, ItalyDepartment of Psychology, Università Cattolica del Sacro Cuore, Milano, ItalyUniToM, Università Cattolica del Sacro Cuore, Milano, ItalyDepartment of Psychology, Università Cattolica del Sacro Cuore, Milano, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyInteruniversity Department of Regional and Urban Studies and Planning (DIST), University of Turin, Turin, ItalyIRCCS Fondazione Don Carlo Gnocchi, Milano, ItalyBackgroundIt has been widely demonstrated that siblings of children with autism spectrum disorder (ASD) have an increased risk of abnormal developmental trajectories. In response to this, early recognition protocols have been developed worldwide, aiming to promote early interventions that can positively impact the neurodevelopment of this population. This paper presents the protocol of a controlled trial: ERI-SIBS (Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders) is an innovative and ecological early recognition and intervention program designed specifically for siblings of children with ASD.MethodsWe aim to recruit siblings at low risk and high risk of neurodevelopmental disorders. Based on clinical evaluation at T0, we will allocate the infants into three groups: Group 1, infants at low risk without any signs of neurodevelopmental disorders; Group 2, infants at high risk without any signs of neurodevelopmental disorders; Group 3: infants at low or high risk with signs suggestive of neurodevelopmental disorders. Children of Group 2 will undergo Active Monitoring (one 90 min session once a month for 6 months), while children of Group 3 will undergo Early Intervention (one 90 min session once a week for 6 months). In both cases, the ERI-SIBS contents are based on a multidimensional and naturalistic approach and always involve caregivers. All recruited children will be evaluated at three different time points (T0 within the 8 months of life of the child, T1 after 6 months and T2 after 12 months) using behavioural, technological, and biological techniques to assess infants’ neurodevelopmental functions, parent-infant interaction, and early ASD markers.DiscussionThe ERI-SIBS study will expand knowledge regarding the impact of early intervention on families of infants at risk of neurodevelopmental disorders for the presence of a child with a diagnosis of ASD. The study will have the potential to significantly contribute to future research and the scientific and clinical debate on the best way to implement early intervention in at-risk populations. Clinical Trial RegistrationClinicaltrials.gov identifier (NCT06512649).https://www.frontiersin.org/articles/10.3389/fped.2024.1467783/fullearly interventionautism spectrum disorderneurodevelopmental disorderssiblingschildren |
| spellingShingle | Silvia Annunziata Giulia Purpura Giulia Purpura Elena Piazza Paolo Meriggi Gabriele Fassina Laura Santos Emilia Ambrosini Antonella Marchetti Antonella Marchetti Federico Manzi Federico Manzi Davide Massaro Davide Massaro Andrea Luna Tacci Andrea Luna Tacci Elisabetta Bolognesi Simone Agostini Francesca La Rosa Alessandra Paola Giulia Pedrocchi Paola Molina Anna Cavallini Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder Frontiers in Pediatrics early intervention autism spectrum disorder neurodevelopmental disorders siblings children |
| title | Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| title_full | Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| title_fullStr | Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| title_full_unstemmed | Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| title_short | Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| title_sort | early recognition and intervention in siblings at high risk for neurodevelopment disorders eri sibs a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder |
| topic | early intervention autism spectrum disorder neurodevelopmental disorders siblings children |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1467783/full |
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