Prior corticosteroid treatment alters cPBMC composition and IFNγ response to immunotherapy in canine cancer

Prior corticosteroid treatment alters cPBMC composition and IFNγ response to immunotherapy in canine cancer

BackgroundImmunotherapy using immune checkpoint inhibitors (ICIs) represents a promising therapeutic approach for canine cancer patients. Similar to human cancer patients, the concurrent use of corticosteroids may attenuate the efficacy of immune checkpoint inhibitors in dogs. In this study, we eval...

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Bibliographic Details
Main Authors: Anna Barbara Emilia Zimmermann, Betül Taskoparan, Daniel Fuchs, Stanislav Pantelyushin, Mathischan Maheswaran, Manuela Schnyder, Sonja Hartnack, Carla Rohrer Bley, Johannes vom Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
immune checkpoint inhibitor
cancer
atezolizumab
gilvetmab
corticosteroid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544949/full
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