How to predict effective drug combinations – moving beyond synergy scores
Summary: To improve our understanding of multi-drug therapies, cancer cell line panels screened with drug combinations are frequently studied using machine learning (ML). ML models trained on such data typically focus on predicting synergy scores that support drug development and repurposing efforts...
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| Main Authors: | Lea Eckhart, Kerstin Lenhof, Lutz Herrmann, Lisa-Marie Rolli, Hans-Peter Lenhof |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225008831 |
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