Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review
The obesity epidemic has become a global public health issue, impacting more than one billion people worldwide. 9% of the US population, or 28.8 million Americans will have an eating disorder in their lifetime. In fact, global eating disorder prevalence increased from 3.5% to 7.8% between 2000 and 2...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1516122/full |
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| author | Colin Hanna Fiona Comstock Shtakshe Chatrath Alan Posner John Butsch Kenneth Blum Kenneth Blum Mark S. Gold Lesley Georger Lucy D. Mastrandrea Teresa Quattrin Panayotis K. Thanos Panayotis K. Thanos |
| author_facet | Colin Hanna Fiona Comstock Shtakshe Chatrath Alan Posner John Butsch Kenneth Blum Kenneth Blum Mark S. Gold Lesley Georger Lucy D. Mastrandrea Teresa Quattrin Panayotis K. Thanos Panayotis K. Thanos |
| author_sort | Colin Hanna |
| collection | DOAJ |
| description | The obesity epidemic has become a global public health issue, impacting more than one billion people worldwide. 9% of the US population, or 28.8 million Americans will have an eating disorder in their lifetime. In fact, global eating disorder prevalence increased from 3.5% to 7.8% between 2000 and 2018. In spite of the fact that less than 6% of people with an eating disorder are medically underweight, it is indeed an important factor when considering issues related to obesity. This public health problem is often described as being caused by various genetic and psychosocial factors. One of the most effective strategies for treating morbid obesity and achieving significant weight loss is bariatric surgery. Recent focus on precision medicine approaches has expanded into bariatric surgery in an effort to better understand and achieve improved outcomes and reduce risk for post-operative weight regain and addiction transfers during the recovery process. Addiction transfers, including substance and non-substance addictions, are well established concerns for post-bariatric patients. This review details the genetic, molecular and psychosocial factors that can be utilized to inform and guide personalized treatment. Additionally, this review details some of the molecular mechanisms including dysregulation of catecholamine signaling as well as other neurotransmitter systems relevant to help further understand recovery science. |
| format | Article |
| id | doaj-art-7f706b6372d7462c87106fbfc730e601 |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-7f706b6372d7462c87106fbfc730e6012025-08-20T02:20:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-05-011310.3389/fpubh.2025.15161221516122Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative reviewColin Hanna0Fiona Comstock1Shtakshe Chatrath2Alan Posner3John Butsch4Kenneth Blum5Kenneth Blum6Mark S. Gold7Lesley Georger8Lucy D. Mastrandrea9Teresa Quattrin10Panayotis K. Thanos11Panayotis K. Thanos12Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biosciences, University at Buffalo, Buffalo, NY, United StatesBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biosciences, University at Buffalo, Buffalo, NY, United StatesBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biosciences, University at Buffalo, Buffalo, NY, United StatesDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United StatesDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United StatesDivision of Addiction Research & Education, Center for Exercise Sports & Global Mental Health, Western University Health Sciences, Pomona, CA, United StatesDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, IsraelDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Natural Sciences and Mathematics, D'Youville University, Buffalo, NY, United StatesUBMD Pediatrics Division of Endocrinology/Diabetes, Buffalo, NY, United StatesUBMD Pediatrics Division of Endocrinology/Diabetes, Buffalo, NY, United StatesBehavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Department of Pharmacology and Toxicology, Clinical Research Institute on Addictions, Jacobs School of Medicine and Biosciences, University at Buffalo, Buffalo, NY, United StatesDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, IsraelThe obesity epidemic has become a global public health issue, impacting more than one billion people worldwide. 9% of the US population, or 28.8 million Americans will have an eating disorder in their lifetime. In fact, global eating disorder prevalence increased from 3.5% to 7.8% between 2000 and 2018. In spite of the fact that less than 6% of people with an eating disorder are medically underweight, it is indeed an important factor when considering issues related to obesity. This public health problem is often described as being caused by various genetic and psychosocial factors. One of the most effective strategies for treating morbid obesity and achieving significant weight loss is bariatric surgery. Recent focus on precision medicine approaches has expanded into bariatric surgery in an effort to better understand and achieve improved outcomes and reduce risk for post-operative weight regain and addiction transfers during the recovery process. Addiction transfers, including substance and non-substance addictions, are well established concerns for post-bariatric patients. This review details the genetic, molecular and psychosocial factors that can be utilized to inform and guide personalized treatment. Additionally, this review details some of the molecular mechanisms including dysregulation of catecholamine signaling as well as other neurotransmitter systems relevant to help further understand recovery science.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1516122/fullobesitydrug abuseaddictionreward deficiencyhypodomanergiagastric bypass |
| spellingShingle | Colin Hanna Fiona Comstock Shtakshe Chatrath Alan Posner John Butsch Kenneth Blum Kenneth Blum Mark S. Gold Lesley Georger Lucy D. Mastrandrea Teresa Quattrin Panayotis K. Thanos Panayotis K. Thanos Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review Frontiers in Public Health obesity drug abuse addiction reward deficiency hypodomanergia gastric bypass |
| title | Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review |
| title_full | Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review |
| title_fullStr | Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review |
| title_full_unstemmed | Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review |
| title_short | Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review |
| title_sort | utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery a narrative review |
| topic | obesity drug abuse addiction reward deficiency hypodomanergia gastric bypass |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1516122/full |
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