Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials
Abstract Objective Our aim was to evaluate long-term effectiveness and safety of cervical disc arthroplasty (CDA) compared to anterior cervical discectomy and fusion (ACDF) in single-segment cervical degenerative disc disease (CDDD). Methods Comprehensive literature searches were performed in four d...
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BMC
2025-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-06189-x |
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| author | Yu Zhang Jidong Ju Jinchun Wu |
| author_facet | Yu Zhang Jidong Ju Jinchun Wu |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Abstract Objective Our aim was to evaluate long-term effectiveness and safety of cervical disc arthroplasty (CDA) compared to anterior cervical discectomy and fusion (ACDF) in single-segment cervical degenerative disc disease (CDDD). Methods Comprehensive literature searches were performed in four databases from their inception until February 6, 2025. Meta-analyses were conducted with use of Stata 17.0. Results Seventeen randomized controlled trials were included in our meta-analysis. CDA group exhibited greater blood loss but demonstrated a higher neurological success rate, an increased range of motion, and lower scores on neck disability index as well as visual analog scales. Additionally, reoperation rates and adjacent segment degeneration rates were significantly reduced in comparison to ACDF group. There were no significant differences between two groups in surgical duration or adverse event rates. Conclusion In the long term, cervical disc arthroplasty presents favorable safety profile for treating single-segment CDDD with lower reoperation rates while demonstrating superior efficacy over ACDF along with effective reduction in adjacent segment degeneration rates. |
| format | Article |
| id | doaj-art-7f6fc2f79ee248f1a3e41e861b8f17aa |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-7f6fc2f79ee248f1a3e41e861b8f17aa2025-08-20T03:43:27ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-08-0120111310.1186/s13018-025-06189-xComparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trialsYu Zhang0Jidong Ju1Jinchun Wu2Department of Orthopaedics, Jingjiang People’s Hospital Affiliated to Yangzhou UniversityDepartment of Orthopaedics, Jingjiang People’s Hospital Affiliated to Yangzhou UniversityDepartment of Orthopaedics, Jingjiang People’s Hospital Affiliated to Yangzhou UniversityAbstract Objective Our aim was to evaluate long-term effectiveness and safety of cervical disc arthroplasty (CDA) compared to anterior cervical discectomy and fusion (ACDF) in single-segment cervical degenerative disc disease (CDDD). Methods Comprehensive literature searches were performed in four databases from their inception until February 6, 2025. Meta-analyses were conducted with use of Stata 17.0. Results Seventeen randomized controlled trials were included in our meta-analysis. CDA group exhibited greater blood loss but demonstrated a higher neurological success rate, an increased range of motion, and lower scores on neck disability index as well as visual analog scales. Additionally, reoperation rates and adjacent segment degeneration rates were significantly reduced in comparison to ACDF group. There were no significant differences between two groups in surgical duration or adverse event rates. Conclusion In the long term, cervical disc arthroplasty presents favorable safety profile for treating single-segment CDDD with lower reoperation rates while demonstrating superior efficacy over ACDF along with effective reduction in adjacent segment degeneration rates.https://doi.org/10.1186/s13018-025-06189-xCervical disc arthroplastyCervical degenerative disc diseaseLong-term efficacyMeta-analysisRandomized controlled trial |
| spellingShingle | Yu Zhang Jidong Ju Jinchun Wu Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials Journal of Orthopaedic Surgery and Research Cervical disc arthroplasty Cervical degenerative disc disease Long-term efficacy Meta-analysis Randomized controlled trial |
| title | Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single-segment cervical degenerative disc disease with a minimum of 4-year follow-up: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | comparison of cervical disc arthroplasty versus anterior cervical discectomy and fusion for the treatment of single segment cervical degenerative disc disease with a minimum of 4 year follow up a systematic review and meta analysis of randomized controlled trials |
| topic | Cervical disc arthroplasty Cervical degenerative disc disease Long-term efficacy Meta-analysis Randomized controlled trial |
| url | https://doi.org/10.1186/s13018-025-06189-x |
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