Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials
Objective. Critical limb ischemia (CLI) is the most dangerous stage of peripheral artery disease (PAD). Many basic researches and clinical treatment had been focused on stem cell transplantation for CLI. This systematic review was performed to review evidence for safety and efficacy of autologous st...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/7528464 |
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| _version_ | 1832556477856874496 |
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| author | Baocheng Xie Houlong Luo Yusheng Zhang Qinghui Wang Chenhui Zhou Daohua Xu |
| author_facet | Baocheng Xie Houlong Luo Yusheng Zhang Qinghui Wang Chenhui Zhou Daohua Xu |
| author_sort | Baocheng Xie |
| collection | DOAJ |
| description | Objective. Critical limb ischemia (CLI) is the most dangerous stage of peripheral artery disease (PAD). Many basic researches and clinical treatment had been focused on stem cell transplantation for CLI. This systematic review was performed to review evidence for safety and efficacy of autologous stem cell therapy in CLI. Methods. A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018. Results. Meta-analysis showed that cell therapy significantly increased the probability of ulcer healing (RR = 1.73, 95% CI = 1.45–2.06), angiogenesis (RR = 5.91, 95% CI = 2.49–14.02), and reduced the amputation rates (RR = 0.59, 95% CI = 0.46–0.76). Ankle-brachial index (ABI) (MD = 0.13, 95% CI = 0.11–0.15), TcO2 (MD = 12.22, 95% CI = 5.03–19.41), and pain-free walking distance (MD = 144.84, 95% CI = 53.03–236.66) were significantly better in the cell therapy group than in the control group (P<0.01). Conclusions. The results of this meta-analysis indicate that autologous stem cell therapy is safe and effective in CLI. However, higher quality and larger RCTs are required for further investigation to support clinical application of stem cell transplantation. |
| format | Article |
| id | doaj-art-7f6cb2dd011c4d9198d050bed67df87f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7f6cb2dd011c4d9198d050bed67df87f2025-02-03T05:45:22ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/75284647528464Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled TrialsBaocheng Xie0Houlong Luo1Yusheng Zhang2Qinghui Wang3Chenhui Zhou4Daohua Xu5Department of Pharmacology, Guangdong Medical University, Dongguan 523808, ChinaInstitute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Pharmacology, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Pharmacology, Guangdong Medical University, Dongguan 523808, ChinaSchool of Nursing, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Pharmacology, Guangdong Medical University, Dongguan 523808, ChinaObjective. Critical limb ischemia (CLI) is the most dangerous stage of peripheral artery disease (PAD). Many basic researches and clinical treatment had been focused on stem cell transplantation for CLI. This systematic review was performed to review evidence for safety and efficacy of autologous stem cell therapy in CLI. Methods. A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018. Results. Meta-analysis showed that cell therapy significantly increased the probability of ulcer healing (RR = 1.73, 95% CI = 1.45–2.06), angiogenesis (RR = 5.91, 95% CI = 2.49–14.02), and reduced the amputation rates (RR = 0.59, 95% CI = 0.46–0.76). Ankle-brachial index (ABI) (MD = 0.13, 95% CI = 0.11–0.15), TcO2 (MD = 12.22, 95% CI = 5.03–19.41), and pain-free walking distance (MD = 144.84, 95% CI = 53.03–236.66) were significantly better in the cell therapy group than in the control group (P<0.01). Conclusions. The results of this meta-analysis indicate that autologous stem cell therapy is safe and effective in CLI. However, higher quality and larger RCTs are required for further investigation to support clinical application of stem cell transplantation.http://dx.doi.org/10.1155/2018/7528464 |
| spellingShingle | Baocheng Xie Houlong Luo Yusheng Zhang Qinghui Wang Chenhui Zhou Daohua Xu Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials Stem Cells International |
| title | Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials |
| title_full | Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials |
| title_short | Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials |
| title_sort | autologous stem cell therapy in critical limb ischemia a meta analysis of randomized controlled trials |
| url | http://dx.doi.org/10.1155/2018/7528464 |
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