Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis
Diffuse large B-cell lymphoma (DLBCL) represents 30-40% of all non-Hodgkin lymphomas (NHL) and is a disease with an aggressive behavior. Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognost...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/8586354 |
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| author | Alexandra Ioana Cioroianu Patricia Irina Stinga Liana Sticlaru Mirela Daniela Cioplea Luciana Nichita Cristiana Popp Florica Staniceanu |
| author_facet | Alexandra Ioana Cioroianu Patricia Irina Stinga Liana Sticlaru Mirela Daniela Cioplea Luciana Nichita Cristiana Popp Florica Staniceanu |
| author_sort | Alexandra Ioana Cioroianu |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) represents 30-40% of all non-Hodgkin lymphomas (NHL) and is a disease with an aggressive behavior. Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognostic and risk stratification biomarkers and new potential therapeutic targets. In contrast to other types of cancers like carcinomas, where tumor microenvironment was widely investigated, its role in DLBCL pathogenesis and patient survival is still poorly understood, although few studies had promising results. The composition of TME and its interaction with neoplastic cells may explain the role of several genes (beta2-microglobulin gene, CD58 gene), receptor-like programmed cell death-1 (PD-1) and its ligand (PD-L1), or other cell components (Treg) in tumor evasion of immune surveillance, resulting in tumor progression. Also, it was found that “gene expression profile” of the microenvironmental cells, the phenotype of tumor-associated macrophages (TAM), the expression of matricellular proteins like SPARC and fibronectin, the overexpression of several types of matrix metalloproteinases (MMPs) like MMP-2 and MMP-9, or the tissue inhibitors of matrix metalloproteinases (TIMPs) may lead to a favorable or adverse outcome. With this review, we try to highlight the influence of microenvironment components over lymphoid clone progression and their prognostic impact in DLBCL patients. |
| format | Article |
| id | doaj-art-7f6c0c93f7054f59b0f1dfcdaee3be00 |
| institution | OA Journals |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-7f6c0c93f7054f59b0f1dfcdaee3be002025-08-20T02:08:42ZengWileyAnalytical Cellular Pathology2210-71772210-71852019-01-01201910.1155/2019/85863548586354Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and PrognosisAlexandra Ioana Cioroianu0Patricia Irina Stinga1Liana Sticlaru2Mirela Daniela Cioplea3Luciana Nichita4Cristiana Popp5Florica Staniceanu6Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaFaculty of Dental Medicine, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, RomaniaDiffuse large B-cell lymphoma (DLBCL) represents 30-40% of all non-Hodgkin lymphomas (NHL) and is a disease with an aggressive behavior. Because about one-third of DLBCL patients will be refractory or resistant to standard therapy, several studies focused on identification of new individual prognostic and risk stratification biomarkers and new potential therapeutic targets. In contrast to other types of cancers like carcinomas, where tumor microenvironment was widely investigated, its role in DLBCL pathogenesis and patient survival is still poorly understood, although few studies had promising results. The composition of TME and its interaction with neoplastic cells may explain the role of several genes (beta2-microglobulin gene, CD58 gene), receptor-like programmed cell death-1 (PD-1) and its ligand (PD-L1), or other cell components (Treg) in tumor evasion of immune surveillance, resulting in tumor progression. Also, it was found that “gene expression profile” of the microenvironmental cells, the phenotype of tumor-associated macrophages (TAM), the expression of matricellular proteins like SPARC and fibronectin, the overexpression of several types of matrix metalloproteinases (MMPs) like MMP-2 and MMP-9, or the tissue inhibitors of matrix metalloproteinases (TIMPs) may lead to a favorable or adverse outcome. With this review, we try to highlight the influence of microenvironment components over lymphoid clone progression and their prognostic impact in DLBCL patients.http://dx.doi.org/10.1155/2019/8586354 |
| spellingShingle | Alexandra Ioana Cioroianu Patricia Irina Stinga Liana Sticlaru Mirela Daniela Cioplea Luciana Nichita Cristiana Popp Florica Staniceanu Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis Analytical Cellular Pathology |
| title | Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis |
| title_full | Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis |
| title_fullStr | Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis |
| title_full_unstemmed | Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis |
| title_short | Tumor Microenvironment in Diffuse Large B-Cell Lymphoma: Role and Prognosis |
| title_sort | tumor microenvironment in diffuse large b cell lymphoma role and prognosis |
| url | http://dx.doi.org/10.1155/2019/8586354 |
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