Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia
ObjectiveThis study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.MethodsThis was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia we...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1601761/full |
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| author | Binyu Xing Cunyi Shen Ting Lin Xiaoning Li Wenjun Tan |
| author_facet | Binyu Xing Cunyi Shen Ting Lin Xiaoning Li Wenjun Tan |
| author_sort | Binyu Xing |
| collection | DOAJ |
| description | ObjectiveThis study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.MethodsThis was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia were randomly divided into two groups. The control group (n = 69) received ambroxol hydrochloride, while the observation group (n = 69) received modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride. Clinical efficacy, Traditional Chinese Medicine symptom scores (fever, cough, expectoration, dyspnea), arterial blood gas indicators [oxygen saturation (SaO2), partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2)], lung function [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF)], and inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)] were evaluated. Adverse events were recorded for both groups.ResultsThe overall efficacy rates in the combined and control groups were 98.55% and 89.86% (P < 0.05). After treatment, in both groups, symptom scores for fever, cough, expectoration, and dyspnea were reduced, with the combined group showing more significant improvement; SaO2 and PaO2 levels increased, and PaCO2 decreased, with the combined group achieving greater improvement; FEV1, FVC, and PEF values increased, with higher values observed in the combined group; serum IL-6, TNF-α, and CRP levels decreased, with the combined group showing more substantial reductions (all P < 0.05). The incidence of adverse events was 4.35% in the combined group and 2.90% in the control group (P > 0.05).ConclusionModified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride demonstrated ideal clinical efficacy in treating severe pneumonia, alleviating symptoms and pulmonary inflammation and improving arterial blood gas indicators and lung function. |
| format | Article |
| id | doaj-art-7f662cbbffd6415da51c0d1ac75cd6d4 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-7f662cbbffd6415da51c0d1ac75cd6d42025-08-20T03:13:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-07-011610.3389/fphys.2025.16017611601761Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumoniaBinyu XingCunyi ShenTing LinXiaoning LiWenjun TanObjectiveThis study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.MethodsThis was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia were randomly divided into two groups. The control group (n = 69) received ambroxol hydrochloride, while the observation group (n = 69) received modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride. Clinical efficacy, Traditional Chinese Medicine symptom scores (fever, cough, expectoration, dyspnea), arterial blood gas indicators [oxygen saturation (SaO2), partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2)], lung function [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF)], and inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP)] were evaluated. Adverse events were recorded for both groups.ResultsThe overall efficacy rates in the combined and control groups were 98.55% and 89.86% (P < 0.05). After treatment, in both groups, symptom scores for fever, cough, expectoration, and dyspnea were reduced, with the combined group showing more significant improvement; SaO2 and PaO2 levels increased, and PaCO2 decreased, with the combined group achieving greater improvement; FEV1, FVC, and PEF values increased, with higher values observed in the combined group; serum IL-6, TNF-α, and CRP levels decreased, with the combined group showing more substantial reductions (all P < 0.05). The incidence of adverse events was 4.35% in the combined group and 2.90% in the control group (P > 0.05).ConclusionModified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride demonstrated ideal clinical efficacy in treating severe pneumonia, alleviating symptoms and pulmonary inflammation and improving arterial blood gas indicators and lung function.https://www.frontiersin.org/articles/10.3389/fphys.2025.1601761/fullsevere pneumoniaShenzhe Zhenqi Decoctionambroxol hydrochlorideblood gas indiceslung functioninflammatory factors |
| spellingShingle | Binyu Xing Cunyi Shen Ting Lin Xiaoning Li Wenjun Tan Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia Frontiers in Physiology severe pneumonia Shenzhe Zhenqi Decoction ambroxol hydrochloride blood gas indices lung function inflammatory factors |
| title | Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| title_full | Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| title_fullStr | Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| title_full_unstemmed | Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| title_short | Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| title_sort | clinical study on modified shenzhe zhenqi decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia |
| topic | severe pneumonia Shenzhe Zhenqi Decoction ambroxol hydrochloride blood gas indices lung function inflammatory factors |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1601761/full |
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