Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data
Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/8720342 |
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| author | Mario Mancini Alice Andreassi Michela Salvioni Fiore Pelliccione Gianna Mantellassi Giuseppe Banderali |
| author_facet | Mario Mancini Alice Andreassi Michela Salvioni Fiore Pelliccione Gianna Mantellassi Giuseppe Banderali |
| author_sort | Mario Mancini |
| collection | DOAJ |
| description | Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. To evaluate this hypothesis, we administered both inositol formulations before carrying out an oral glucose tolerance test (OGTT) in a group of obese insulin-resistant male children with high basal insulin levels and compared the values obtained with an OGTT previously conducted without inositol, in the same group, with unchanged BMI. Our results confirm that myoinositol and D-chiro inositol acutely reduce insulin increase after glucose intake mainly in children with high basal insulin level. |
| format | Article |
| id | doaj-art-7f640fe8f0194d0ea05c13964f888254 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7f640fe8f0194d0ea05c13964f8882542025-02-03T01:11:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/87203428720342Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary DataMario Mancini0Alice Andreassi1Michela Salvioni2Fiore Pelliccione3Gianna Mantellassi4Giuseppe Banderali5Pediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyPediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyPediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyPediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyPediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyPediatrics and Adolescent Andrological Project, Department of Pediatrics, San Paolo Hospital, Via di Rudini 8, University of Milan, 20142 Milan, ItalyMyoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. To evaluate this hypothesis, we administered both inositol formulations before carrying out an oral glucose tolerance test (OGTT) in a group of obese insulin-resistant male children with high basal insulin levels and compared the values obtained with an OGTT previously conducted without inositol, in the same group, with unchanged BMI. Our results confirm that myoinositol and D-chiro inositol acutely reduce insulin increase after glucose intake mainly in children with high basal insulin level.http://dx.doi.org/10.1155/2016/8720342 |
| spellingShingle | Mario Mancini Alice Andreassi Michela Salvioni Fiore Pelliccione Gianna Mantellassi Giuseppe Banderali Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data International Journal of Endocrinology |
| title | Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data |
| title_full | Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data |
| title_fullStr | Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data |
| title_full_unstemmed | Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data |
| title_short | Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data |
| title_sort | myoinositol and d chiro inositol in improving insulin resistance in obese male children preliminary data |
| url | http://dx.doi.org/10.1155/2016/8720342 |
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