Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population
Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease aver...
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BioMed Central
2014-09-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-12-121.pdf |
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| author | Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek |
| author_facet | Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek |
| author_sort | Incheol Seo |
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| description | Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, p = 4.87 × 10-7), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium (r2 > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies. |
| format | Article |
| id | doaj-art-7f631a5bedd14d4a921942a61843a639 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-7f631a5bedd14d4a921942a61843a6392025-02-02T15:44:46ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-09-0112312112610.5808/GI.2014.12.3.12194Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean PopulationIncheol Seo0Seong-Il Suh1Min-Ho Suh2Won-Ki Baek3Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Department of Microbiology, Keimyung University School of Medicine, Daegu 704-701, Korea.Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, p = 4.87 × 10-7), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium (r2 > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.http://genominfo.org/upload/pdf/gni-12-121.pdfchronic diseasegenome-wide association studymedication adherencemedication compliance |
| spellingShingle | Incheol Seo Seong-Il Suh Min-Ho Suh Won-Ki Baek Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population Genomics & Informatics chronic disease genome-wide association study medication adherence medication compliance |
| title | Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
| title_full | Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
| title_fullStr | Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
| title_full_unstemmed | Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
| title_short | Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population |
| title_sort | genome wide association study of medication adherence in chronic diseases in the korean population |
| topic | chronic disease genome-wide association study medication adherence medication compliance |
| url | http://genominfo.org/upload/pdf/gni-12-121.pdf |
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