Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective

<b>Background</b>. Influenza remains a significant public health issue, with seasonal trends varying across regions. This study provides a comprehensive analysis of influenza virus trends in Italy, leveraging epidemiological and virological data from the Istituto Superiore di Sanità (ISS...

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Main Authors: Francesco Branda , Nicola Petrosillo , Dong Keon Yon , Massimo Ciccozzi , Fabio Scarpa 
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Infectious Disease Reports
Subjects:
Online Access:https://www.mdpi.com/2036-7449/17/2/20
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author Francesco Branda 
Nicola Petrosillo 
Dong Keon Yon 
Massimo Ciccozzi 
Fabio Scarpa 
author_facet Francesco Branda 
Nicola Petrosillo 
Dong Keon Yon 
Massimo Ciccozzi 
Fabio Scarpa 
author_sort Francesco Branda 
collection DOAJ
description <b>Background</b>. Influenza remains a significant public health issue, with seasonal trends varying across regions. This study provides a comprehensive analysis of influenza virus trends in Italy, leveraging epidemiological and virological data from the Istituto Superiore di Sanità (ISS). The primary objective is to assess influenza activity at both national and regional levels, highlighting variations in incidence rates and viral subtype circulation during the 2023/2024 season. <b>Methods</b>. We conducted a systematic approach to data collection, processing, and visualization, utilizing influenza surveillance data from ISS. Incidence rates, subtype distribution, and co-circulating respiratory viruses were analyzed to identify key trends. <b>Results</b>. Our findings reveal a significant increase in influenza cases during the 2023/2024 season, with incidence rates surpassing pre-pandemic levels. Notably, changes in the circulation of influenza A(H3N2) and influenza B were observed, alongside the presence of other respiratory viruses such as RSV and rhinovirus. <b>Conclusions</b>. This study underscores the importance of real-time surveillance, transparent data sharing, and advanced visualization tools in guiding public health responses. By integrating lessons from COVID-19, we highlight the necessity of standardized surveillance frameworks to enhance preparedness for future seasonal outbreaks and potential pandemics.
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spelling doaj-art-7f62df81d16f4a0aa05fdbfaee04449e2025-08-20T02:18:03ZengMDPI AGInfectious Disease Reports2036-74492025-02-011722010.3390/idr17020020Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional PerspectiveFrancesco Branda 0Nicola Petrosillo 1Dong Keon Yon 2Massimo Ciccozzi 3Fabio Scarpa 4Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyInfection Prevention & Control/Infectious Disease Service, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, ItalyCenter for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul 02448, Republic of KoreaUnit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy<b>Background</b>. Influenza remains a significant public health issue, with seasonal trends varying across regions. This study provides a comprehensive analysis of influenza virus trends in Italy, leveraging epidemiological and virological data from the Istituto Superiore di Sanità (ISS). The primary objective is to assess influenza activity at both national and regional levels, highlighting variations in incidence rates and viral subtype circulation during the 2023/2024 season. <b>Methods</b>. We conducted a systematic approach to data collection, processing, and visualization, utilizing influenza surveillance data from ISS. Incidence rates, subtype distribution, and co-circulating respiratory viruses were analyzed to identify key trends. <b>Results</b>. Our findings reveal a significant increase in influenza cases during the 2023/2024 season, with incidence rates surpassing pre-pandemic levels. Notably, changes in the circulation of influenza A(H3N2) and influenza B were observed, alongside the presence of other respiratory viruses such as RSV and rhinovirus. <b>Conclusions</b>. This study underscores the importance of real-time surveillance, transparent data sharing, and advanced visualization tools in guiding public health responses. By integrating lessons from COVID-19, we highlight the necessity of standardized surveillance frameworks to enhance preparedness for future seasonal outbreaks and potential pandemics.https://www.mdpi.com/2036-7449/17/2/20human metapneumovirus (hMPV)influenza A(H3N2)influenza A(H1N1)pdm2009influenza Brespiratory syncytial virus (RSV)rhinovirus
spellingShingle Francesco Branda 
Nicola Petrosillo 
Dong Keon Yon 
Massimo Ciccozzi 
Fabio Scarpa 
Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
Infectious Disease Reports
human metapneumovirus (hMPV)
influenza A(H3N2)
influenza A(H1N1)pdm2009
influenza B
respiratory syncytial virus (RSV)
rhinovirus
title Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
title_full Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
title_fullStr Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
title_full_unstemmed Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
title_short Comprehensive Analysis of Influenza Viruses’ Trends in Italy: Insights from a Nationwide and Regional Perspective
title_sort comprehensive analysis of influenza viruses trends in italy insights from a nationwide and regional perspective
topic human metapneumovirus (hMPV)
influenza A(H3N2)
influenza A(H1N1)pdm2009
influenza B
respiratory syncytial virus (RSV)
rhinovirus
url https://www.mdpi.com/2036-7449/17/2/20
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