Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports
Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less c...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1479877/full |
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| author | Anna Annunziata Giuseppe Fiorentino Antonietta Coppola Rosa Cauteruccio Laura Ferrentino Luigi Fiorentino Cecilia Calabrese |
| author_facet | Anna Annunziata Giuseppe Fiorentino Antonietta Coppola Rosa Cauteruccio Laura Ferrentino Luigi Fiorentino Cecilia Calabrese |
| author_sort | Anna Annunziata |
| collection | DOAJ |
| description | Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This article presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications. |
| format | Article |
| id | doaj-art-7f616fcf21704983a4a044501acd939e |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-7f616fcf21704983a4a044501acd939e2025-08-20T01:56:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14798771479877Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reportsAnna Annunziata0Giuseppe Fiorentino1Antonietta Coppola2Rosa Cauteruccio3Laura Ferrentino4Luigi Fiorentino5Cecilia Calabrese6Department of Intensive Care, Unit of Pathophysiology and Respiratory Rehabilitation, AORN Ospedali dei Colli, Naples, ItalyDepartment of Intensive Care, Unit of Pathophysiology and Respiratory Rehabilitation, AORN Ospedali dei Colli, Naples, ItalyDepartment of Intensive Care, Unit of Pathophysiology and Respiratory Rehabilitation, AORN Ospedali dei Colli, Naples, ItalyDepartment of Intensive Care, Unit of Pathophysiology and Respiratory Rehabilitation, AORN Ospedali dei Colli, Naples, ItalyDepartment of Translational Medical Sciences, University Federico II, Naples, ItalyDepartment of Intensive Care, Unit of Pathophysiology and Respiratory Rehabilitation, AORN Ospedali dei Colli, Naples, ItalyDepartment of Translational Medical Sciences, University of Campania ‘Luigi Vanvitelli’, AORN Ospedali dei Colli, Naples, ItalyAlpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This article presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications.https://www.frontiersin.org/articles/10.3389/fmed.2024.1479877/fullalpha-1 antitrypsin deficiencypregnancyaugmentation therapyemphysemasafetybronchial asthma |
| spellingShingle | Anna Annunziata Giuseppe Fiorentino Antonietta Coppola Rosa Cauteruccio Laura Ferrentino Luigi Fiorentino Cecilia Calabrese Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports Frontiers in Medicine alpha-1 antitrypsin deficiency pregnancy augmentation therapy emphysema safety bronchial asthma |
| title | Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports |
| title_full | Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports |
| title_fullStr | Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports |
| title_full_unstemmed | Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports |
| title_short | Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports |
| title_sort | alpha 1 antitripsyn deficiency and augmentation therapy in pregnancy two case reports |
| topic | alpha-1 antitrypsin deficiency pregnancy augmentation therapy emphysema safety bronchial asthma |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1479877/full |
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