PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses

PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses

Abstract VISA/MAVS is crucial in antiviral innate immunity. Upon RNA virus infection, VISA recruits TBK1 via TRAFs to mitochondria, inducing IRF3 phosphorylation and type I interferons. However, TBK1 recruitment mechanisms via individual TRAFs are unclear. Here, we reveal that PWWP domain-containing...

Full description

Saved in:
Bibliographic Details
Main Authors: Mengling Shi, Cong Wang, Zhen Chen, Yidan Zhou, Liang Yue, Yu Liu, Tiannan Guo, Jun Shang, Haotian Xu, Yu Zhang, Mengcheng Luo, Caoqi Lei
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59421-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items