Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety
The review outlines modern concepts of the relevance of fixed-dose combination therapy comprising angiotensin-converting enzyme inhibitor and dihydropyridine calcium channel antagonist as an antihypertensive component with the HMG-CoA reductase inhibitor when treating hypertensive pat...
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| Format: | Article |
| Language: | Russian |
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InterMedservice
2023-10-01
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| Series: | Евразийский Кардиологический Журнал |
| Subjects: | |
| Online Access: | https://www.heartj.asia/jour/article/view/6407 |
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| author | A. N. Kuchmin T. S. Sveklina P. D. Oktysyuk A. I. Rechkalova V. V. Konyaev |
| author_facet | A. N. Kuchmin T. S. Sveklina P. D. Oktysyuk A. I. Rechkalova V. V. Konyaev |
| author_sort | A. N. Kuchmin |
| collection | DOAJ |
| description | The review outlines modern concepts of the relevance of fixed-dose combination therapy comprising angiotensin-converting enzyme inhibitor and dihydropyridine calcium channel antagonist as an antihypertensive component with the HMG-CoA reductase inhibitor when treating hypertensive patients. We have identified the realms of its possible clinical use taking into consideration the comorbidity peculiarities. In addition, we provide main features of the current drugs’ clinical pharmacodynamics and outline their role in real clinical practice. Nevertheless the emphasis was placed on the modern single-pill combination of amlodipin, atorvastatin and perindopril. We concisely report the results data collected from the large, randomized, double-blind major clinical trials regarding the effectiveness of single pill combination of amlodipine, atorvastatin and perindopril , primary focusing on their cardioprotective features and overall safety profile. |
| format | Article |
| id | doaj-art-7f5e1611256340d8adfa5d612c9bacab |
| institution | Kabale University |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj-art-7f5e1611256340d8adfa5d612c9bacab2025-08-20T03:37:31ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482023-10-0103768010.38109/2225-1685-2023-3-76-806312Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safetyA. N. Kuchmin0T. S. Sveklina1P. D. Oktysyuk2A. I. Rechkalova3V. V. Konyaev4S.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyS.M. Kirov Military Medical AcademyThe review outlines modern concepts of the relevance of fixed-dose combination therapy comprising angiotensin-converting enzyme inhibitor and dihydropyridine calcium channel antagonist as an antihypertensive component with the HMG-CoA reductase inhibitor when treating hypertensive patients. We have identified the realms of its possible clinical use taking into consideration the comorbidity peculiarities. In addition, we provide main features of the current drugs’ clinical pharmacodynamics and outline their role in real clinical practice. Nevertheless the emphasis was placed on the modern single-pill combination of amlodipin, atorvastatin and perindopril. We concisely report the results data collected from the large, randomized, double-blind major clinical trials regarding the effectiveness of single pill combination of amlodipine, atorvastatin and perindopril , primary focusing on their cardioprotective features and overall safety profile.https://www.heartj.asia/jour/article/view/6407arterial hypertensioncardiovascular diseasescombination of drugscardiovascular therapy |
| spellingShingle | A. N. Kuchmin T. S. Sveklina P. D. Oktysyuk A. I. Rechkalova V. V. Konyaev Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety Евразийский Кардиологический Журнал arterial hypertension cardiovascular diseases combination of drugs cardiovascular therapy |
| title | Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| title_full | Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| title_fullStr | Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| title_full_unstemmed | Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| title_short | Fixed triple combination of amlodipine, perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| title_sort | fixed triple combination of amlodipine perindopril and atorvastatin in the focus of cardiovascular effectiveness and safety |
| topic | arterial hypertension cardiovascular diseases combination of drugs cardiovascular therapy |
| url | https://www.heartj.asia/jour/article/view/6407 |
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