EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY
Aim. To study the morphological features of loose fibrous connective tissue (LFCT) and myocardial contractility in patients with mitral valve prolapse before and after magnesium orotate course.Material and methods. Patients (n=59) with mitral valve prolapse and the phenotype of undifferentiated conn...
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/94 |
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| author | A. G. Avtandilov K. M. Dzeranova T. G. Borovaya L. V. Didenko |
| author_facet | A. G. Avtandilov K. M. Dzeranova T. G. Borovaya L. V. Didenko |
| author_sort | A. G. Avtandilov |
| collection | DOAJ |
| description | Aim. To study the morphological features of loose fibrous connective tissue (LFCT) and myocardial contractility in patients with mitral valve prolapse before and after magnesium orotate course.Material and methods. Patients (n=59) with mitral valve prolapse and the phenotype of undifferentiated connective tissue dysplasia (UCTD) were included into the study. A comprehensive morphological analysis of skin biopsy samples was performed to assess morphological and functional changes of LFCT. Standard echocardiography with the assessment of mitral flow was performed in all participants at baseline and after 8 weeks of magnesium orotate intake.Results. According to morphometry increase in proportion of amorphous matrix was found in LFCT sections after 8-week magnesium orotate course compared to baseline (38.6±0.4% and 23.9 ± 0.4%, respectively; p<0.001). According to the echocardiography increase in the end-diastolic (from 4.9±0.04 cm to 5.05±0.03 cm; p<0.05), and the end-sys- tolic (from 2.9±0.04 cm to 3.0±0.03 cm; p<0.01) left ventricular diameters was observed after 8 weeks of treatment as well as improvement of left ventricular diastolic func- tion (E/A raised from 1.42±0.02 to 1.79±0.04; p<0.01).Conclusion. In patients with mitral valve prolapse and UCTD the 8-week magnesium orotate course led to a significant increase in amorphous part of the matrix, improvement of diffusion ability and architectonics of the connective tissue that determines the improvement of flexibility and extensibility. |
| format | Article |
| id | doaj-art-7f582fac6b1f49aca0d03d12ba022333 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-7f582fac6b1f49aca0d03d12ba0223332025-08-23T10:00:15ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-019439039710.20996/1819-6446-2013-9-4-390-39793EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDYA. G. Avtandilov0K. M. Dzeranova1T. G. Borovaya2L. V. Didenko3Russian Medical Academy of Postgraduate Education, MoscowRussian Medical Academy of Postgraduate Education, MoscowScientific Research Institute of Epidemiology and Microbiology named after N.F. Gamaleya, MoscowScientific Research Institute of Epidemiology and Microbiology named after N.F. Gamaleya, MoscowAim. To study the morphological features of loose fibrous connective tissue (LFCT) and myocardial contractility in patients with mitral valve prolapse before and after magnesium orotate course.Material and methods. Patients (n=59) with mitral valve prolapse and the phenotype of undifferentiated connective tissue dysplasia (UCTD) were included into the study. A comprehensive morphological analysis of skin biopsy samples was performed to assess morphological and functional changes of LFCT. Standard echocardiography with the assessment of mitral flow was performed in all participants at baseline and after 8 weeks of magnesium orotate intake.Results. According to morphometry increase in proportion of amorphous matrix was found in LFCT sections after 8-week magnesium orotate course compared to baseline (38.6±0.4% and 23.9 ± 0.4%, respectively; p<0.001). According to the echocardiography increase in the end-diastolic (from 4.9±0.04 cm to 5.05±0.03 cm; p<0.05), and the end-sys- tolic (from 2.9±0.04 cm to 3.0±0.03 cm; p<0.01) left ventricular diameters was observed after 8 weeks of treatment as well as improvement of left ventricular diastolic func- tion (E/A raised from 1.42±0.02 to 1.79±0.04; p<0.01).Conclusion. In patients with mitral valve prolapse and UCTD the 8-week magnesium orotate course led to a significant increase in amorphous part of the matrix, improvement of diffusion ability and architectonics of the connective tissue that determines the improvement of flexibility and extensibility.https://www.rpcardio.online/jour/article/view/94mitral valve prolapsediastolic functionconnective tissuedysplasia syndromeundifferentiated connective tissuecollagenconnective tissue matrix |
| spellingShingle | A. G. Avtandilov K. M. Dzeranova T. G. Borovaya L. V. Didenko EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY Рациональная фармакотерапия в кардиологии mitral valve prolapse diastolic function connective tissue dysplasia syndrome undifferentiated connective tissue collagen connective tissue matrix |
| title | EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY |
| title_full | EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY |
| title_fullStr | EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY |
| title_full_unstemmed | EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY |
| title_short | EFFECT OF MAGNESIUM OROTATE ON CONNECTIVE TISSUE MATRIX AND CARDIAC INOTROPIC FUNCTION IN PATIENTS WITH MITRAL VALVE PROLAPSE. CLINICAL AND MORPHOLOGICAL STUDY |
| title_sort | effect of magnesium orotate on connective tissue matrix and cardiac inotropic function in patients with mitral valve prolapse clinical and morphological study |
| topic | mitral valve prolapse diastolic function connective tissue dysplasia syndrome undifferentiated connective tissue collagen connective tissue matrix |
| url | https://www.rpcardio.online/jour/article/view/94 |
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