Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers
Postprandial dysmetabolism, which refers to the impaired regulation of glucose and lipid levels after meals, is recognized as an independent risk factor for cardiovascular diseases (CVDs). Diets rich in polyphenols have demonstrated potential in improving postprandial hyperglycemia and hyperlipidemi...
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MDPI AG
2025-07-01
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| Online Access: | https://www.mdpi.com/2076-3417/15/14/7857 |
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| author | Panagiota Potsaki Olga I. Papagianni Kalliopi Almpounioti Charalampos Soulakellis Angeliki Voutsa Olga Katira Vasiliki Bountziouka Charalampos Karantonis Antonios E. Koutelidakis |
| author_facet | Panagiota Potsaki Olga I. Papagianni Kalliopi Almpounioti Charalampos Soulakellis Angeliki Voutsa Olga Katira Vasiliki Bountziouka Charalampos Karantonis Antonios E. Koutelidakis |
| author_sort | Panagiota Potsaki |
| collection | DOAJ |
| description | Postprandial dysmetabolism, which refers to the impaired regulation of glucose and lipid levels after meals, is recognized as an independent risk factor for cardiovascular diseases (CVDs). Diets rich in polyphenols have demonstrated potential in improving postprandial hyperglycemia and hyperlipidemia. This study investigates the effects of olive leaf polyphenols on postprandial metabolic outcomes following a high-fat and high-carbohydrate meal. A total of 36 healthy adults participated in a three-arm randomized crossover trial. They ingested either a biscuit made from olive leaf powder (OLB), olive leaf tea (OLT), or a placebo meal (CTRL) to assess the impact of olive leaf polyphenols on postprandial glycemia, lipid levels, platelet aggregation factor (PAF), and plasma antioxidant status (TAC). Although no statistically significant differences were observed in the primary biomarkers, including glucose and lipid profiles, a delayed insulin response was noted in the interventions involving olive leaf. These findings suggest that while acute olive leaf supplementation did not significantly alter postprandial glycemia or lipidemia, it may subtly influence insulin kinetics. Further research is needed to explore the long-term effects of olive leaf polyphenols on metabolic health, especially in populations at risk for CVDs. |
| format | Article |
| id | doaj-art-7f55e0185bad4b59a2ff05ca961b210c |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-7f55e0185bad4b59a2ff05ca961b210c2025-08-20T03:36:15ZengMDPI AGApplied Sciences2076-34172025-07-011514785710.3390/app15147857Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy VolunteersPanagiota Potsaki0Olga I. Papagianni1Kalliopi Almpounioti2Charalampos Soulakellis3Angeliki Voutsa4Olga Katira5Vasiliki Bountziouka6Charalampos Karantonis7Antonios E. Koutelidakis8Laboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreeceLaboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreeceLaboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreeceLaboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreeceOutpatient Clinic, 81400 Myrina, GreeceOutpatient Clinic, 81400 Myrina, GreeceLaboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreeceLaboratory of Food Chemistry, Biochemistry and Technology, Food Science and Nutrition Department, University of the Aegean, 11472 Myrina, GreeceLaboratory of Nutrition and Public Health, Unit of Human Nutrition, Department of Food Science and Nutrition, University of the Aegean, 10 Ierou Lochou & Makrygianni Str., 81400 Myrina, GreecePostprandial dysmetabolism, which refers to the impaired regulation of glucose and lipid levels after meals, is recognized as an independent risk factor for cardiovascular diseases (CVDs). Diets rich in polyphenols have demonstrated potential in improving postprandial hyperglycemia and hyperlipidemia. This study investigates the effects of olive leaf polyphenols on postprandial metabolic outcomes following a high-fat and high-carbohydrate meal. A total of 36 healthy adults participated in a three-arm randomized crossover trial. They ingested either a biscuit made from olive leaf powder (OLB), olive leaf tea (OLT), or a placebo meal (CTRL) to assess the impact of olive leaf polyphenols on postprandial glycemia, lipid levels, platelet aggregation factor (PAF), and plasma antioxidant status (TAC). Although no statistically significant differences were observed in the primary biomarkers, including glucose and lipid profiles, a delayed insulin response was noted in the interventions involving olive leaf. These findings suggest that while acute olive leaf supplementation did not significantly alter postprandial glycemia or lipidemia, it may subtly influence insulin kinetics. Further research is needed to explore the long-term effects of olive leaf polyphenols on metabolic health, especially in populations at risk for CVDs.https://www.mdpi.com/2076-3417/15/14/7857olive leafpostprandial metabolismfunctional foodsrandomized controlled trial |
| spellingShingle | Panagiota Potsaki Olga I. Papagianni Kalliopi Almpounioti Charalampos Soulakellis Angeliki Voutsa Olga Katira Vasiliki Bountziouka Charalampos Karantonis Antonios E. Koutelidakis Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers Applied Sciences olive leaf postprandial metabolism functional foods randomized controlled trial |
| title | Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers |
| title_full | Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers |
| title_fullStr | Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers |
| title_full_unstemmed | Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers |
| title_short | Acute Effects of Olive Leaf Tea and Olive Leaf Powder Biscuits on Postprandial Glycemia, Lipid Profile and Inflammatory Markers: A Randomized Controlled Crossover Trial in Healthy Volunteers |
| title_sort | acute effects of olive leaf tea and olive leaf powder biscuits on postprandial glycemia lipid profile and inflammatory markers a randomized controlled crossover trial in healthy volunteers |
| topic | olive leaf postprandial metabolism functional foods randomized controlled trial |
| url | https://www.mdpi.com/2076-3417/15/14/7857 |
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