Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)
The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agent...
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| Format: | Article |
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Столичная издательская компания
2022-07-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2755 |
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| author | A. S. Pisaryuk V. A. Zamarashkina N. B. Safarova N. M. Povalyaev E. O. Kotova U. I. Babukhina E. M. Koltsova Zh. D. Kobalava |
| author_facet | A. S. Pisaryuk V. A. Zamarashkina N. B. Safarova N. M. Povalyaev E. O. Kotova U. I. Babukhina E. M. Koltsova Zh. D. Kobalava |
| author_sort | A. S. Pisaryuk |
| collection | DOAJ |
| description | The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agents (mostly bacteria) to be cloaked from the immune system and to multiply freely, leading to growth of vegetation, thus resulting in higher chance of fragmentation. Small-scale experimental and clinical studies on the correction of hemostatic disorders in infective endocarditis, that were performed in 20th century, didn’t show any significant results, that could affect clinical practice. However, reinterpretation of available data on coagulative system will allow to have elements of hemostasis as an application point in treating infective endocarditis. The article will discuss latest insights on the role of hemostasis system in pathophysisology of infective endocarditis, its effects on the development of the embolic complications, perspectives for diagnostics and treatment. |
| format | Article |
| id | doaj-art-7f533ffdbcd84eb6b628c89c6f0ec14a |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-7f533ffdbcd84eb6b628c89c6f0ec14a2025-08-23T10:00:35ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532022-07-0118332033110.20996/1819-6446-2022-06-142033Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)A. S. Pisaryuk0V. A. Zamarashkina1N. B. Safarova2N. M. Povalyaev3E. O. Kotova4U. I. Babukhina5E. M. Koltsova6Zh. D. Kobalava7RUDN University; Moscow City Hospital named after V.V. VinogradovRUDN UniversityLomonosov Moscow State UniversityRUDN UniversityRUDN UniversityA.N. Bakulev Research Center for Cardiovascular SurgeryCenter for Theoretical Problems of Physicochemical Pharmacology; Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and ImmunologyRUDN UniversityThe issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agents (mostly bacteria) to be cloaked from the immune system and to multiply freely, leading to growth of vegetation, thus resulting in higher chance of fragmentation. Small-scale experimental and clinical studies on the correction of hemostatic disorders in infective endocarditis, that were performed in 20th century, didn’t show any significant results, that could affect clinical practice. However, reinterpretation of available data on coagulative system will allow to have elements of hemostasis as an application point in treating infective endocarditis. The article will discuss latest insights on the role of hemostasis system in pathophysisology of infective endocarditis, its effects on the development of the embolic complications, perspectives for diagnostics and treatment.https://www.rpcardio.online/jour/article/view/2755infective endocarditisimmunothrombosishemostasisembolic eventsbiomarkers of coagulation and fibrinolysisprevention of embolismantithrombotic therapy |
| spellingShingle | A. S. Pisaryuk V. A. Zamarashkina N. B. Safarova N. M. Povalyaev E. O. Kotova U. I. Babukhina E. M. Koltsova Zh. D. Kobalava Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) Рациональная фармакотерапия в кардиологии infective endocarditis immunothrombosis hemostasis embolic events biomarkers of coagulation and fibrinolysis prevention of embolism antithrombotic therapy |
| title | Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) |
| title_full | Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) |
| title_fullStr | Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) |
| title_full_unstemmed | Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) |
| title_short | Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review) |
| title_sort | coagulation disorders in infective endocarditis role of pathogens biomarkers antithrombotic therapy systematic review |
| topic | infective endocarditis immunothrombosis hemostasis embolic events biomarkers of coagulation and fibrinolysis prevention of embolism antithrombotic therapy |
| url | https://www.rpcardio.online/jour/article/view/2755 |
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