Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy
Highlights Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy. Functionalized the cascade reaction sy...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | Nano-Micro Letters |
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| Online Access: | https://doi.org/10.1007/s40820-025-01735-y |
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| _version_ | 1849342518310731776 |
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| author | Hengke Liu Shan Lei Hongyu Li Jiayingzi Wu Ting He Jing Lin Peng Huang |
| author_facet | Hengke Liu Shan Lei Hongyu Li Jiayingzi Wu Ting He Jing Lin Peng Huang |
| author_sort | Hengke Liu |
| collection | DOAJ |
| description | Highlights Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy. Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects. |
| format | Article |
| id | doaj-art-7f43eddf589b42a48bb54ecedd546192 |
| institution | Kabale University |
| issn | 2311-6706 2150-5551 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj-art-7f43eddf589b42a48bb54ecedd5461922025-08-20T03:43:21ZengSpringerOpenNano-Micro Letters2311-67062150-55512025-05-0117111410.1007/s40820-025-01735-yRefining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic TherapyHengke Liu0Shan Lei1Hongyu Li2Jiayingzi Wu3Ting He4Jing Lin5Peng Huang6Marshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityMarshall Laboratory of Biomedical Engineering, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics (LET), International Cancer Center, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen UniversityHighlights Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy. Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects.https://doi.org/10.1007/s40820-025-01735-ySingle-atom nanozymesGlucose oxidaseBiomimetic cascade catalysisTumor catalytic therapyMild-temperature photothermal therapy |
| spellingShingle | Hengke Liu Shan Lei Hongyu Li Jiayingzi Wu Ting He Jing Lin Peng Huang Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy Nano-Micro Letters Single-atom nanozymes Glucose oxidase Biomimetic cascade catalysis Tumor catalytic therapy Mild-temperature photothermal therapy |
| title | Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy |
| title_full | Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy |
| title_fullStr | Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy |
| title_full_unstemmed | Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy |
| title_short | Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy |
| title_sort | refining single atom catalytic kinetics for tumor homologous targeted catalytic therapy |
| topic | Single-atom nanozymes Glucose oxidase Biomimetic cascade catalysis Tumor catalytic therapy Mild-temperature photothermal therapy |
| url | https://doi.org/10.1007/s40820-025-01735-y |
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