Association of circulating immuno-oncology biomarkers with breast cancer risk: insights from two prospective cohorts
Abstract Immuno-oncology biomarkers are promising tools for cancer risk assessment and early detection. To identify and validate their associations with breast cancer, nested case-control studies within the Taizhou Longitudinal Study (TZL) cohort and the UK biobank Pharma Proteomics Project (UKB-PPP...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-01019-z |
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| Summary: | Abstract Immuno-oncology biomarkers are promising tools for cancer risk assessment and early detection. To identify and validate their associations with breast cancer, nested case-control studies within the Taizhou Longitudinal Study (TZL) cohort and the UK biobank Pharma Proteomics Project (UKB-PPP) were conducted, comprising 195 and 881 incident breast cancer patients, together with their matched controls. Among the 92 plasma proteins tested by the Olink Immuno-oncology panel, 11 proteins were associated with breast cancer risk in the TZL cohort after multiple testing correction. Notably, hepatocyte growth factor (HGF) was validated in the UKB-PPP, particularly among postmenopausal women (OR = 1.13, 95% CI = 1.03–1.24). The association was stronger with Estrogen Receptor-negative breast cancer and confirmed by Mendelian Randomization analysis. Additionally, HGF mediated the effects of Healthy Lifestyle Index (27.17%) and BMI (19.79%) on breast cancer risk. Therefore, HGF could be an intervention target by either medicines or lifestyle changes to improve the prevention and treatment of breast cancer. |
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| ISSN: | 2397-768X |