The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation
Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria t...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2017-08-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/the-yin-yang-of-mitochondrial-architecture-interplay-of-micos-and-f1fo-atp-synthase-in-cristae-formation/ |
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| _version_ | 1850034963686096896 |
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| author | Heike Rampelt Martin van der Laan |
| author_facet | Heike Rampelt Martin van der Laan |
| author_sort | Heike Rampelt |
| collection | DOAJ |
| description | Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria to adapt to changing physiological requirements. The mito-chondrial contact site and cristae organizing system (MICOS) and the oligomeric ATP synthase have been known to govern distinct features of cristae architec-ture. A new study [1] on the crosstalk between these two machineries now sheds light on the mechanisms of cristae formation and maintenance. |
| format | Article |
| id | doaj-art-7f40be9010ed45ae97c3cb297ae9ed30 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-7f40be9010ed45ae97c3cb297ae9ed302025-08-20T02:57:39ZengShared Science Publishers OGMicrobial Cell2311-26382017-08-014823623910.15698/mic2017.08.583The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formationHeike Rampelt0Martin van der Laan1Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.Medical Biochemistry and Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University, School of Medicine, 66421 Homburg, Germany.Oxidative phosphorylation takes place at specialized compartments of the inner mitochondrial membrane, the cristae. The elaborate ultrastructure of cristae membranes enables efficient chemi-osmotic coupling of respiratory chain and F1Fo-ATP synthase. Dynamic membrane remodeling allows mitochondria to adapt to changing physiological requirements. The mito-chondrial contact site and cristae organizing system (MICOS) and the oligomeric ATP synthase have been known to govern distinct features of cristae architec-ture. A new study [1] on the crosstalk between these two machineries now sheds light on the mechanisms of cristae formation and maintenance.http://microbialcell.com/researcharticles/the-yin-yang-of-mitochondrial-architecture-interplay-of-micos-and-f1fo-atp-synthase-in-cristae-formation/mitochondriacristaemembrane architecturecontact siteMICOSF1Fo-ATP synthaseMic10respiration |
| spellingShingle | Heike Rampelt Martin van der Laan The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation Microbial Cell mitochondria cristae membrane architecture contact site MICOS F1Fo-ATP synthase Mic10 respiration |
| title | The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation |
| title_full | The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation |
| title_fullStr | The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation |
| title_full_unstemmed | The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation |
| title_short | The Yin & Yang of Mitochondrial Architecture - Interplay of MICOS and F1Fo-ATP synthase in cristae formation |
| title_sort | yin yang of mitochondrial architecture interplay of micos and f1fo atp synthase in cristae formation |
| topic | mitochondria cristae membrane architecture contact site MICOS F1Fo-ATP synthase Mic10 respiration |
| url | http://microbialcell.com/researcharticles/the-yin-yang-of-mitochondrial-architecture-interplay-of-micos-and-f1fo-atp-synthase-in-cristae-formation/ |
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