Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor
A 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendoc...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/391086 |
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| author | Kocfa Chung-Delgado Alejandro Revilla-Montag Sonia Guillén-Bravo Hugo Ríos-Díaz José C. Alva-Muñoz |
| author_facet | Kocfa Chung-Delgado Alejandro Revilla-Montag Sonia Guillén-Bravo Hugo Ríos-Díaz José C. Alva-Muñoz |
| author_sort | Kocfa Chung-Delgado |
| collection | DOAJ |
| description | A 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3
to 109,000 platelets/mm3. Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was evidenced (4000 platelets/mm3). The present case report highlights the possible association between octreotide treatment and a severe thrombocytopenia resistant to conventional treatment. |
| format | Article |
| id | doaj-art-7f40bc882ef34a0bb12352dfc4bf0748 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-7f40bc882ef34a0bb12352dfc4bf07482025-02-03T01:12:49ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/391086391086Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine TumorKocfa Chung-Delgado0Alejandro Revilla-Montag1Sonia Guillén-Bravo2Hugo Ríos-Díaz3José C. Alva-Muñoz4Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 33, PeruEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 33, PeruEscuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 33, PeruHematology Department, Hospital Nacional “Edgardo Rebagliati Martins”, Lima 33, PeruClinical Pathology Department, Hospital Nacional “Edgardo Rebagliati Martins”, Lima 33, PeruA 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3 to 109,000 platelets/mm3. Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was evidenced (4000 platelets/mm3). The present case report highlights the possible association between octreotide treatment and a severe thrombocytopenia resistant to conventional treatment.http://dx.doi.org/10.1155/2013/391086 |
| spellingShingle | Kocfa Chung-Delgado Alejandro Revilla-Montag Sonia Guillén-Bravo Hugo Ríos-Díaz José C. Alva-Muñoz Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor Case Reports in Hematology |
| title | Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor |
| title_full | Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor |
| title_fullStr | Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor |
| title_full_unstemmed | Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor |
| title_short | Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor |
| title_sort | refractory thrombocytopenia responds to octreotide treatment in a case of evans syndrome with gastric neuroendocrine tumor |
| url | http://dx.doi.org/10.1155/2013/391086 |
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