The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis
Conventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration. Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures. Autologous fat grafting has been proposed for reconstructi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/120949 |
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| author | Riccardo Schweizer Wakako Tsuji Vijay S. Gorantla Kacey G. Marra J. Peter Rubin Jan A. Plock |
| author_facet | Riccardo Schweizer Wakako Tsuji Vijay S. Gorantla Kacey G. Marra J. Peter Rubin Jan A. Plock |
| author_sort | Riccardo Schweizer |
| collection | DOAJ |
| description | Conventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration. Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures. Autologous fat grafting has been proposed for reconstructive purposes for decades to restore form and anatomy after mastectomy. Fat has the inherent advantage of being autologous tissue and the most natural-appearing filler, but given its inconsistent engraftment and retention rates, it lacks reliability. Implementation of autologous fat grafts with cellular adjuncts, such as multipotent adipose-derived stem cells (ADSCs), has shown promising results. However, it is pertinent and critical to question whether these cells could promote any residual tumor cells to proliferate, differentiate, or metastasize or even induce de novo carcinogenesis. Thus far, preclinical and clinical study findings are discordant. A trend towards potential promotion of both breast cancer growth and invasion by ADSCs found in basic science studies was indeed not confirmed in clinical trials. Whether experimental findings eventually correlate with or will be predictive of clinical outcomes remains unclear. Herein, we aimed to concisely review current experimental findings on the interaction of mesenchymal stem cells and breast cancer, mainly focusing on ADSCs as a promising tool for regenerative medicine, and discuss the implications in clinical translation. |
| format | Article |
| id | doaj-art-7f35ccc9b9534cd396a46c67dc2fce38 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7f35ccc9b9534cd396a46c67dc2fce382025-02-03T06:08:14ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/120949120949The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and MetastasisRiccardo Schweizer0Wakako Tsuji1Vijay S. Gorantla2Kacey G. Marra3J. Peter Rubin4Jan A. Plock5Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8006 Zurich, SwitzerlandDepartment of Surgery, Shiga Medical Center for Adults, Shiga 524-8525, JapanMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USAAdipose Stem Cell Center, Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USAAdipose Stem Cell Center, Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8006 Zurich, SwitzerlandConventional breast cancer extirpation involves resection of parts of or the whole gland, resulting in asymmetry and disfiguration. Given the unsatisfactory aesthetic outcomes, patients often desire postmastectomy reconstructive procedures. Autologous fat grafting has been proposed for reconstructive purposes for decades to restore form and anatomy after mastectomy. Fat has the inherent advantage of being autologous tissue and the most natural-appearing filler, but given its inconsistent engraftment and retention rates, it lacks reliability. Implementation of autologous fat grafts with cellular adjuncts, such as multipotent adipose-derived stem cells (ADSCs), has shown promising results. However, it is pertinent and critical to question whether these cells could promote any residual tumor cells to proliferate, differentiate, or metastasize or even induce de novo carcinogenesis. Thus far, preclinical and clinical study findings are discordant. A trend towards potential promotion of both breast cancer growth and invasion by ADSCs found in basic science studies was indeed not confirmed in clinical trials. Whether experimental findings eventually correlate with or will be predictive of clinical outcomes remains unclear. Herein, we aimed to concisely review current experimental findings on the interaction of mesenchymal stem cells and breast cancer, mainly focusing on ADSCs as a promising tool for regenerative medicine, and discuss the implications in clinical translation.http://dx.doi.org/10.1155/2015/120949 |
| spellingShingle | Riccardo Schweizer Wakako Tsuji Vijay S. Gorantla Kacey G. Marra J. Peter Rubin Jan A. Plock The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis Stem Cells International |
| title | The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis |
| title_full | The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis |
| title_fullStr | The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis |
| title_full_unstemmed | The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis |
| title_short | The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis |
| title_sort | role of adipose derived stem cells in breast cancer progression and metastasis |
| url | http://dx.doi.org/10.1155/2015/120949 |
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