Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction.

Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction.

A single HIV-1 variant establishes infection of the host after sexual contact. Identifying the phenotypic characteristics of these Transmitted Founder (T/F) viruses is important to understand the restriction mechanisms during transmission. Langerhans cells (LCs) are the mucosal dendritic cell subset...

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Main Authors: Nina Hertoghs, Bernadien M Nijmeijer, Nienke H van Teijlingen, Angharad E Fenton-May, Tanja M Kaptein, John L van Hamme, John C Kappes, Neeltje A Kootstra, Beatrice H Hahn, Persephone Borrow, Carla M S Ribeiro, Teunis B H Geijtenbeek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226651&type=printable
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